Synthesis of L-azetidine-2-carboxylic acid

被引：0
作者：
Jin, Jian-zhong [1 ]
Zhang, Jie [2 ]
机构：
[1] Zhejiang Shuren Univ, Coll Biol & Environm Engn, Hangzhou, Zhejiang, Peoples R China
[2] Chinese Acad Sci, Jiaxing Res Ctr Appl Chem, Jiaxing, Zhejiang, Peoples R China
来源：
2011 INTERNATIONAL CONFERENCE ON FUZZY SYSTEMS AND NEURAL COMPUTING (FSNC 2011), VOL III | 2011年
关键词：
L-azetidine-2-carboxylic acid; synthesis; tertbutyl ester; hydrogenation; resolution; AZETIDINE-2-CARBOXYLIC ACID;
D O I：
暂无
中图分类号：
TQ [化学工业];
学科分类号：
0817 ;
摘要：
L-Azetidine-2-carboxylic acid, the first known example naturally occurring azetidine, was synthesized in a novel, simple, clean and improved procedure. It was synthesized from gamma-butyrolactone through four steps: bromination and esterification, cyclization, hydrogenation and resolution. The overall yield could reach 13.2%.
引用
收藏
页码：118 / 120
页数：3
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