Bilateral transcranial direct current stimulation attenuated symptoms of alcohol use disorder: A systematic review and meta-analysis

Background: Alcohol use disorder is one of the common substance use disorders leading to mental and health problems. Despite the potential positive effects of transcranial direct current stimulation (tDCS) on symptoms of various substance use disorder, how specific tDCS protocols effectively influence on individuals with alcohol use disorder is still controversial. This systematic review and meta-analysis investigated beneficial effects of tDCS on symptoms of alcohol use disorder. Method: Eighteen total studies met our inclusion criteria, and we used 25 total comparisons from the qualified studies for the data synthesis. We estimated effect sizes by quantifying changes in alcohol craving and consumption between active tDCS protocol and sham groups. In addition, three moderator variable analyses determined whether tDCS effects on symptoms of alcohol use disorder were different based on (a) bilateral versus unilateral tDCS protocols, (b) specific targeted regions, and (c) multiple sessions versus single session of tDCS protocols. Results: Random-effects model meta-analysis revealed small positive tDCS effects on alcohol craving and consumption. Specifically, bilateral tDCS protocols significantly reduced alcohol craving, and further anodal tDCS on right dorsolateral prefrontal cortex (DLPFC) and cathodal tDCS on left DLPFC revealed significant positive effects. The multiple sessions of tDCS protocols showed better effects on reducing alcohol craving. Conclusions: The current findings suggested that bilateral tDCS protocols including anodal tDCS on right DLPFC and cathodal tDCS on left DLPFC with multiple sessions may effectively improve tDCS effects on symptoms of alcohol use disorder.