Protective effects of echinocystic acid isolated from Gleditsia sinensis Lam. against acute myocardial ischemia

被引：23

作者：

Wu, Jianming ^{[1
,2
]}

Li, Jian ^{[3
]}

Zhu, Zhiyong ^{[1
]}

Li, Jiang ^{[1
]}

Huang, Guojun ^{[2
]}

Tang, Yao ^{[3
]}

Gao, Xiaoping ^{[1
]}

机构：

[1] Kang Hong Pharmaceut Grp, Chengdu 610036, Peoples R China

[2] Chengdu Univ Tradit Chinese Med, Chengdu, Peoples R China

[3] Sichuan Univ, W China Hosp, Chengdu 610064, Peoples R China

来源：

FITOTERAPIA | 2010年 / 81卷 / 01期

关键词：

Gleditsia sinensis; Echinocystic acid; Myocardial ischemia; Isoproterenol; Vasopressin; Bcl-2; APOPTOSIS; INDUCTION; EXTRACT; MODELS; FRUIT; RATS;

D O I：

10.1016/j.fitote.2009.06.015

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Echinocystic acid (EA), a pentacyclic triterpene, was isolated and identified from the fruits of Gleditsia sinensis Lam. The protective effects of EA were evaluated in rat models with acute myocardial ischemia induced by isoproterenol and vasopressin. In the electrocardiogram of anesthetized rats, EA prevented the ST-segment depression induced by isoproterenol or vasopressin in a dose-dependently manner. Furthermore, the mRNA expression of Bcl-2 was analyzed by RT-PCR. EA shows an elevation of Bcl-2 mRNA level in infarcted tissue induced by isoproterenol in rats. These results demonstrated for the first time EA has a cardioprotective effect and may be a natural drug. (C) 2009 Elsevier B.V. All rights reserved.

引用

页码：8 / 10

页数：3

共 9 条

[1]

Chow LMC, 2003, ONCOL REP, V10, P1601

[2] Antiproliferative activity of the extract of Gleditsia sinensis fruit on human solid tumour cell lines [J].

Chow, LMC ;

Tang, JCO ;

Teo, ITN ;

Chui, CH ;

Lau, FY ;

Leung, TWT ;

Cheng, G ;

Wong, RSM ;

Wong, ILK ;

Tsang, KMS ;

Tan, WQ ;

Zhao, YZ ;

Lai, KB ;

Lam, WH ;

Guo, DA ;

Chan, ASC .

CHEMOTHERAPY, 2002, 48 (06) :303-308

[3]

[丁云录 DING Yunlu], 2006, [中国新药与临床杂志, Chinese Journal of New Drugs and Clinical Remedies], V25, P110

[4]

[丁云录 DING Yunlu], 2006, [天然产物研究与开发, Natural Product R & D], V18, P275

[5] EFFECT OF KRN2391, A NOVEL VASODILATOR, ON VARIOUS EXPERIMENTAL ANGINAL MODELS IN RATS [J].

HARADA, K ;

FUKATA, Y ;

MIWA, A ;

KANETA, S ;

FUKUSHIMA, H ;

OGAWA, N .

JAPANESE JOURNAL OF PHARMACOLOGY, 1993, 63 (01) :35-39

[6]

Liang J.Y., 2003, CHIN WILD PLANT RESO, V22, P44

[7] Effect of SMP-300, a new Na+/H+ exchange inhibitor, on myocardial ischemia and experimental angina models in rats [J].

Yamamoto, S ;

Matsui, K ;

Sasabe, M ;

Kitano, M ;

Ohashi, N .

JAPANESE JOURNAL OF PHARMACOLOGY, 2000, 84 (02) :196-205

[8] Structure-activity relationships of saponins from Gleditsia sinensis in cytotoxicity and induction of apoptosis [J].

Zhong, L ;

Li, P ;

Han, J ;

Qu, GQ ;

Guo, D .

PLANTA MEDICA, 2004, 70 (09) :797-802

[9]

Zhong L, 2003, PLANTA MED, V69, P561, DOI 10.1055/s-2003-40645

← 1 →