Pathogenesis and therapy of psoriasis

被引：1438
作者：
Lowes, Michelle A.
Bowcock, Anne M.
Krueger, James G.
机构：
[1] Rockefeller Univ, Invest Dermatol Lab, New York, NY 10021 USA
[2] Washington Univ, Sch Med, Dept Genet, St Louis, MO 63110 USA
来源：
NATURE | 2007年 / 445卷 / 7130期
基金：
美国国家卫生研究院;
关键词：
D O I：
10.1038/nature05663
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Psoriasis is one of the most common human skin diseases and is considered to have key genetic underpinnings. It is characterized by excessive growth and aberrant differentiation of keratinocytes, but is fully reversible with appropriate therapy. The trigger of the keratinocyte response is thought to be activation of the cellular immune system, with T cells, dendritic cells and various immune-related cytokines and chemokines implicated in pathogenesis. The newest therapies for psoriasis target its immune components and may predict potential treatments for other inflammatory human diseases.
引用
收藏
页码：866 / 873
页数：8
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