Targeting the SASP to combat ageing: Mitochondria as possible intracellular allies?

被引:62
作者
Birch, Jodie [1 ]
Passos, Joao F. [1 ]
机构
[1] Newcastle Univ, Inst Ageing, Inst Cell & Mol Biosci, Campus Ageing & Vital, Newcastle Upon Tyne, Tyne & Wear, England
基金
英国生物技术与生命科学研究理事会;
关键词
ageing; mitochondria; SASP; senescence; senolytics; DNA-DAMAGE-RESPONSE; KAPPA-B ACTIVATION; SENESCENT CELLS; CELLULAR SENESCENCE; TELOMERE DYSFUNCTION; CLEARANCE; DEHYDROGENASE; ACCUMULATION; METABOLISM; GLYCOLYSIS;
D O I
10.1002/bies.201600235
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Anti-senescence therapies, such as drugs that specifically kill senescent cells, to stave off ageing are currently under investigation. While these interventions show promise, their potential pitfalls are discussed herein. We have shown that the mitochondria are essential for development of senescence and many of the associated phenotypes, including the often detrimental senescence-associated secretory phenotype (SASP). Here, we disentangle many ways in which the mitochondria may influence senescence and development of the SASP and focus on possible pathways that could be exploited for future generation of anti-senescence therapies with a clear aim; to specifically eliminate the problematic features of senescent cells, while maintaining their beneficial characteristics.
引用
收藏
页数:7
相关论文
共 62 条
[11]   Mitochondria are required for pro-ageing features of the senescent phenotype [J].
Correia-Melo, Clara ;
Marques, Francisco D. M. ;
Anderson, Rhys ;
Hewitt, Graeme ;
Hewitt, Rachael ;
Cole, John ;
Carroll, Bernadette M. ;
Miwa, Satomi ;
Birch, Jodie ;
Merz, Alina ;
Rushton, Michael D. ;
Charles, Michelle ;
Jurk, Diana ;
Tait, Stephen W. G. ;
Czapiewski, Rafal ;
Greaves, Laura ;
Nelson, Glyn ;
Bohlooly-Y, Mohammad ;
Rodriguez-Cuenca, Sergio ;
Vidal-Puig, Antonio ;
Mann, Derek ;
Saretzki, Gabriele ;
Quarato, Giovanni ;
Green, Douglas R. ;
Adams, Peter D. ;
von Zglinicki, Thomas ;
Korolchuk, Viktor I. ;
Passos, Joao F. .
EMBO JOURNAL, 2016, 35 (07) :724-742
[12]   An Essential Role for Senescent Cells in Optimal Wound Healing through Secretion of PDGF-AA [J].
Demaria, Marco ;
Ohtani, Naoko ;
Youssef, Sameh A. ;
Rodier, Francis ;
Toussaint, Wendy ;
Mitchell, James R. ;
Laberge, Remi-Martin ;
Vijg, Jan ;
Van Steeg, Harry ;
Dolle, Martijn E. T. ;
Hoeijmakers, Jan H. J. ;
de Bruin, Alain ;
Hara, Eiji ;
Campisi, Judith .
DEVELOPMENTAL CELL, 2014, 31 (06) :722-733
[13]   Differential Roles for the Interferon-Inducible IFI16 and AIM2 Innate Immune Sensors for Cytosolic DNA in Cellular Senescence of Human Fibroblasts [J].
Duan, Xin ;
Ponomareva, Larissa ;
Veeranki, Sudhakar ;
Panchanathan, Ravichandran ;
Dickerson, Eric ;
Choubey, Divaker .
MOLECULAR CANCER RESEARCH, 2011, 9 (05) :589-602
[14]   Poly(ADP-Ribose) Polymerase Inhibitor Induces Accelerated Senescence in Irradiated Breast Cancer Cells and Tumors [J].
Efimova, Elena V. ;
Mauceri, Helena J. ;
Golden, Daniel W. ;
Labay, Edwardine ;
Bindokas, Vytautas P. ;
Darga, Thomas E. ;
Chakraborty, Chaitali ;
Barreto-Andrade, Juan Camilo ;
Crawley, Clayton ;
Sutton, Harold G. ;
Kron, Stephen J. ;
Weichselbaum, Ralph R. .
CANCER RESEARCH, 2010, 70 (15) :6277-6282
[15]   Mitochondrial DNA in the regulation of innate immune responses [J].
Fang, Chunju ;
Wei, Xiawei ;
Wei, Yuquan .
PROTEIN & CELL, 2016, 7 (01) :11-16
[16]   Inflammatory networks during cellular senescence: causes and consequences [J].
Freund, Adam ;
Orjalo, Arturo V. ;
Desprez, Pierre-Yves ;
Campisi, Judith .
TRENDS IN MOLECULAR MEDICINE, 2010, 16 (05) :238-246
[17]   Telomeric DNA damage is irreparable and causes persistent DNA-damage-response activation [J].
Fumagalli, Marzia ;
Rosiello, Francesca ;
Clerici, Michela ;
Barozzi, Sara ;
Cittaro, Davide ;
Kaplunov, Jessica M. ;
Bucci, Gabriele ;
Dobreva, Miryana ;
Matti, Valentina ;
Beausejour, Christian M. ;
Herbig, Utz ;
Longhese, Maria Pia ;
di Fagagna, Fabrizio d'Adda .
NATURE CELL BIOLOGY, 2012, 14 (04) :355-+
[18]   Mammalian Sirtuins: Biological Insights and Disease Relevance [J].
Haigis, Marcia C. ;
Sinclair, David A. .
ANNUAL REVIEW OF PATHOLOGY-MECHANISMS OF DISEASE, 2010, 5 :253-295
[19]   AMPK: a nutrient and energy sensor that maintains energy homeostasis [J].
Hardie, D. Grahame ;
Ross, Fiona A. ;
Hawley, Simon A. .
NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2012, 13 (04) :251-262
[20]   Rapamycin fed late in life extends lifespan in genetically heterogeneous mice [J].
Harrison, David E. ;
Strong, Randy ;
Sharp, Zelton Dave ;
Nelson, James F. ;
Astle, Clinton M. ;
Flurkey, Kevin ;
Nadon, Nancy L. ;
Wilkinson, J. Erby ;
Frenkel, Krystyna ;
Carter, Christy S. ;
Pahor, Marco ;
Javors, Martin A. ;
Fernandez, Elizabeth ;
Miller, Richard A. .
NATURE, 2009, 460 (7253) :392-U108