Inhibition of the G2 DNA damage checkpoint by oliveroline isolated from Duguetia odorata

被引：16

作者：

Brastianos, Harry C.

Sturgeon, Christopher M.

Roberge, Michel ^{[1
]}

Andersen, Raymond J.

机构：

[1] Univ British Columbia, Dept Biochem & Mol Biol, Vancouver, BC V6T 1Z1, Canada

[2] Univ British Columbia, Dept Chem, Vancouver, BC V6T 1Z1, Canada

[3] Univ British Columbia, Dept Earth & Ocean Sci, Vancouver, BC V6T 1Z1, Canada

来源：

JOURNAL OF NATURAL PRODUCTS | 2007年 / 70卷 / 02期

关键词：

D O I：

10.1021/np060285e

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Plant extracts obtained from the U.S. National Cancer Institute's Open Repository collection have been screened for their ability to inhibit the G(2) DNA damage checkpoint. An extract of Duguetia odorata showed promising activity in the assay. Bioassay-guided fractionation revealed that oliveroline (1) was responsible for the G(2) checkpoint inhibitory activity of the D. odorata extract. The new alkaloid N-methylguatterine (2) was identified during this investigation.

引用

页码：287 / 288

页数：2

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