共 21 条
Effects of Alzheimer's disease and Lewy body disease on subcortical atrophy
被引:11
作者:
Yoo, H. S.
[1
]
Lee, E. C.
[2
]
Chung, S. J.
[1
]
Lee, Y. H.
[1
]
Lee, S. G.
[3
]
Yun, M.
[4
]
Lee, P. H.
[1
]
Sohn, Y. H.
[1
]
Seong, J. -K.
[2
,5
]
Ye, B. S.
[1
]
机构:
[1] Yonsei Univ, Coll Med, Dept Neurol, 50-1 Yonsei Ro, Seoul 03722, South Korea
[2] Korea Univ, Dept Bioconvergence Engn, Seoul, South Korea
[3] Yonsei Univ, Coll Med, Dept Radiol, Seoul, South Korea
[4] Yonsei Univ, Coll Med, Dept Nucl Med, Seoul, South Korea
[5] Korea Univ, Sch Biomed Engn, Seoul, South Korea
基金:
新加坡国家研究基金会;
关键词:
Alzheimer's disease;
cognitive impairment;
dementia with Lewy bodies;
Parkinson's disease;
subcortical atrophy;
MILD COGNITIVE IMPAIRMENT;
PARKINSONS-DISEASE;
PATHOLOGY;
DEMENTIA;
BRAIN;
BODIES;
IMPACT;
D O I:
10.1111/ene.14080
中图分类号:
R74 [神经病学与精神病学];
学科分类号:
摘要:
Background and purpose Subcortical structures are affected by neurodegeneration in Alzheimer's disease (AD) and Lewy body disease (LBD). Although the co-occurrence of AD and LBD pathologies and their possible interaction have been reported, the effect of AD and LBD on subcortical structures remains unknown. The effects of AD and LBD on subcortical atrophy and their relationship with cognitive dysfunction were investigated. Methods The cross-sectional study recruited 42 patients with pure AD related cognitive impairment (ADCI), 30 patients with pure LBD related cognitive impairment (LBCI), 58 patients with mixed ADCI and LBCI, and 29 normal subjects. A general linear model was used to compare subcortical volume and shape amongst the groups, to investigate the independent and interaction effects of ADCI and LBCI on subcortical shape and volume, and to analyze the relationship between subcortical volume and cognitive dysfunction in each group. Results Alzheimer's disease related cognitive impairment and LBCI were independently associated with subcortical atrophies in the hippocampus and amygdala and in the hippocampus and putamen respectively, but their interaction effect was not significant. Compared to the control group, the pure LBCI group exhibited additional local atrophies in the amygdala, caudate and thalamus. Subcortical atrophies correlated differently with cognitive dysfunction according to the underlying causes of cognitive dysfunction. Conclusions The patterns of subcortical atrophies and their correlation with cognitive dysfunction differ according to the underlying AD, LBD or concomitant AD and LBD.
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页码:318 / 326
页数:9
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