Biologically based dose-response model for liver tumors induced by trichloroethylene

被引:15
作者
Chen, CW [1 ]
机构
[1] US EPA, Natl Ctr Environm Assessment, Washington, DC 20460 USA
关键词
DCA; dose-response model; liver tumor; TCA; TCE;
D O I
10.1289/ehp.00108s2335
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
The existing extensive laboratory data on trichloroethylene (TCE) and its two metabolites, dichloroacetic (DCA) and trichloroacetic (TCA), are used to explore the relationship among these three compounds. Under the hypothesis that these compounds induce liver turners in mice through promotion of preexisting initiated cells, it is demonstrated that DCA alone could be responsible for all the response of carcinomas in liver of B6CF(1) mice. The focus of this paper is on how a plausible biological assumption could impact on low-lose risk estimates, rather than on the risk estimate per se. The findings suggest that low-dose risk estimates to humans would be overestimated unless the different background rates between mice and humans are properly accounted for.
引用
收藏
页码:335 / 342
页数:8
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