Registration of serial SPECT/CT images for three-dimensional dosimetry in radionuclide therapy

被引:23
|
作者
Sjogreen-Gleisner, K. [1 ]
Rueckert, D. [2 ]
Ljungberg, M. [1 ]
机构
[1] Lund Univ, Dept Med Radiat Phys, S-22100 Lund, Sweden
[2] Univ London Imperial Coll Sci Technol & Med, Dept Comp, London, England
来源
PHYSICS IN MEDICINE AND BIOLOGY | 2009年 / 54卷 / 20期
基金
瑞典研究理事会;
关键词
ACTIVITY QUANTIFICATION; ANTIBODY THERAPY; LYMPHOMA; I-131; CT; SIMULATION;
D O I
10.1088/0031-9155/54/20/010
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
For radionuclide therapy, individual patient pharmacokinetics can be measured in three dimensions by sequential SPECT imaging. Accurate registration of the time series of images is central for voxel-based calculations of the residence time and absorbed dose. In this work, rigid and non-rigid methods are evaluated for registration of 6-7 SPECT/CT images acquired over a week, in anatomical regions from the head-and-neck region down to the pelvis. A method for calculation of the absorbed dose, including a voxel mass determination from the CT images, is also described. Registration of the SPECT/CT images is based on a CT-derived spatial transformation. Evaluation is focused on the CT registration accuracy, and on its impact on values of residence time and absorbed dose. According to the CT evaluation, the non-rigid method produces a more accurate registration than the rigid one. For images of the residence time and absorbed dose, registration produces a sharpening of the images. For volumes-of-interest, the differences between rigid and non-rigid results are generally small. However, the non-rigid method is more consistent for regions where non-rigid patient movements are likely, such as in the head-neck-shoulder region.
引用
收藏
页码:6181 / 6200
页数:20
相关论文
共 50 条
  • [1] Three-dimensional registration and analysis for brain SPECT images
    Liao, YL
    Sun, YN
    Chiu, NT
    2004 IEEE NUCLEAR SCIENCE SYMPOSIUM CONFERENCE RECORD, VOLS 1-7, 2004, : 2715 - 2719
  • [2] Improved dosimetry for targeted radionuclide therapy using nonrigid registration on sequential SPECT images
    Ao, Edwin C. I.
    Wu, Nien-Yun
    Wang, Shyh-Jen
    Song, Na
    Mok, Greta S. P.
    MEDICAL PHYSICS, 2015, 42 (02) : 1060 - 1070
  • [3] Registration of three-dimensional magnetic resonance and radionuclide skeletal images
    Wong, TZ
    Connolly, LP
    Treves, ST
    CLINICAL NUCLEAR MEDICINE, 1999, 24 (11) : 859 - 863
  • [4] An automated voxelized dosimetry tool for radionuclide therapy based on serial quantitative SPECT/CT imaging
    Jackson, Price A.
    Beauregard, Jean-Mathieu
    Hofman, Michael S.
    Kron, Tomas
    Hogg, Annette
    Hicks, Rodney J.
    MEDICAL PHYSICS, 2013, 40 (11)
  • [5] Application of three-dimensional dosimetry to multiple treatments of radionuclide therapy.
    Flux, GD
    Guy, ML
    Papavasileiou, P
    Chittenden, S
    Pomeroy, KM
    Meller, S
    Vini, L
    Flower, M
    JOURNAL OF NUCLEAR MEDICINE, 2001, 42 (05) : 22P - 22P
  • [6] The importance of the accuracy of image registration of SPECT images for 3D targeted radionuclide therapy dosimetry
    Papavasileiou, Periklis
    Divoli, Antigoni
    Hatziioannou, Konstantinos
    Flux, Glenn D.
    PHYSICS IN MEDICINE AND BIOLOGY, 2007, 52 (24): : N539 - N548
  • [7] Three-dimensional registration of myocardial perfusion SPECT and CT coronary angiography
    Hidenobu Nakajo
    Shin-ichiro Kumita
    Keiichi Cho
    Tatsuo Kumazaki
    Annals of Nuclear Medicine, 2005, 19 : 207 - 215
  • [8] Three-dimensional registration of myocardial perfusion SPECT and CT coronary angiography
    Nakajo, H
    Kumita, S
    Cho, K
    Kumazaki, T
    ANNALS OF NUCLEAR MEDICINE, 2005, 19 (03) : 207 - 215
  • [9] Quantitative SPECT/CT for Dosimetry of Peptide Receptor Radionuclide Therapy
    Kennedy, John
    Chicheportiche, Alexandre
    Keidar, Zohar
    SEMINARS IN NUCLEAR MEDICINE, 2022, 52 (02) : 229 - 242
  • [10] Comparison of Sequential SPECT and CT for Targeted Radionuclide Therapy Dosimetry
    Li, T.
    Leong, K.
    Ao, E.
    Mok, G. S.
    EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2015, 42 : S333 - S333