New Insights Into the Role of Autoreactive CD8 T Cells and Cytokines in Human Type 1 Diabetes

被引：40

作者：

Bender, Christine ^{[1
]}

Rajendran, Sakthi ^{[1
,2
]}

von Herrath, Matthias G. ^{[1
]}

机构：

[1] La Jolla Inst Immunol, Type 1 Diabet Ctr, Ctr Autoimmun & Inflammat, La Jolla, CA 92037 USA

[2] Nationwide Childrens Hosp, Columbus, OH USA

来源：

FRONTIERS IN ENDOCRINOLOGY | 2021年 / 11卷

基金：

美国国家卫生研究院;

关键词：

type; 1; diabetes; autoreactive CD8 T cells; human pancreas; beta cells; cytokines; ENDOPLASMIC-RETICULUM STRESS; PANCREATIC BETA-CELLS; RECENT-ONSET; CLASS-I; ISLET INFLAMMATION; EXPRESSION; PROINSULIN; ANTIGEN; OVEREXPRESSION; INFILTRATION;

D O I：

10.3389/fendo.2020.606434

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Since the establishment of the network for pancreatic organ donors with diabetes (nPOD), we have gained unprecedented insight into the pathology of human type 1 diabetes. Many of the pre-existing "dogmas", mostly derived from studies of animal models and sometimes limited human samples, have to be revised now. For example, we have learned that autoreactive CD8 T cells are present even in healthy individuals within the exocrine pancreas. Furthermore, their "attraction" to islets probably relies on beta-cell intrinsic events, such as the over-expression of MHC class I and resulting presentation of autoantigens such as (prepro)insulin. In addition, we are discovering other signs of beta-cell dysfunction, possibly at least in part due to stress, such as the over-expression of certain cytokines. This review summarizes the latest developments focusing on cytokines and autoreactive CD8 T cells in human type 1 diabetes pathogenesis.

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页数：6

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