Effect of psyllium in hypercholesterolemia at two monounsaturated fatty acid intakes

被引:31
作者
Jenkins, DJA
Wolever, TMS
Vidgen, E
Kendall, CWC
Ransom, TPP
Mehling, CC
Mueller, S
Cunnane, SC
OConnell, NC
Setchell, KDR
Lau, H
Teitel, JM
Garvey, MB
Fulgoni, V
Connelly, PW
Patten, R
Corey, PN
机构
[1] ST MICHAELS HOSP,DIV ENDOCRINOL,TORONTO,ON M5B 1W8,CANADA
[2] ST MICHAELS HOSP,DIV HEMATOL,TORONTO,ON M5B 1W8,CANADA
[3] ST MICHAELS HOSP,DIV CLIN BIOCHEM,TORONTO,ON M5B 1W8,CANADA
[4] UNIV TORONTO,DEPT NUTR SCI,TORONTO,ON,CANADA
[5] UNIV TORONTO,DEPT BIOSTAT & PREVENT MED,TORONTO,ON,CANADA
[6] KELLOGG CO,BATTLE CREEK,MI
[7] CHILDRENS HOSP,MED CTR,CLIN MASS SPECTROMETRY CTR,CINCINNATI,OH 45229
关键词
fiber; psyllium; canola oil; monounsaturated fat; low-density-lipoprotein cholesterol; high-density-lipoprotein cholesterol; blood pressure; clotting factors; monounsaturated fatty acid;
D O I
10.1093/ajcn/65.5.1524
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
We performed two studies to determine whether the lipid-lowering effect of viscous soluble fiber was modified by monounsaturated fatty acid (MUFA). First, psyllium (1.4 g/MJ) was compared with wheat bran (control) in 1-mo metabolic diets by using a randomized crossover design (n = 32 hyperlipidemic subjects). The background diet contained approximate to 6% of energy as MUFA (20% of total fat). The second study (n = 27 hyperlipidemic subjects) was similar to the first but the background diet contained approximate to 12% MUFA (29% of total fat) because of the addition of canola oil. At both fat intakes, psyllium resulted in significant reductions in total, low-density-lipoprotein (LDL), and high-density-lipoprotein (HDL) cholesterol-compared with the wheat bran control. For the psyllium diet at 6% compared with 12% MUFA, the decreases in LDL cholesterol were 12.3 +/- 1.5% (P < 0.001) and 15.3 +/- 2.4% (P < 0.001), respectively. With the higher MUFA diet triacylglycerol fell significantly over the control phase (16.6 +/- 5.5%, P = 0.006) and the ratio of LDL to HDL cholesterol fell significantly over the psyllium phase (7.3 +/- 2.8%, P = 0.015). Psyllium and MUFA intakes were negatively related to the percentage change in the ratio of LDL to HDL cholesterol (r = -0.34, P = 0.019 and r = -0.44, P = 0.002, respectively). Chenodeoxycholate synthesis rate increased (30 +/- 13%, P = 0.038) with the psyllium diet in the 12 subjects in whom this was assessed. We conclude that psyllium lowered LDL- and HDL-cholesterol concentrations similarly at both MUFA intakes. However, there may be some advantage in combining soluble fiber and MUFA to reduce the ratio of LDL to HDL cholesterol.
引用
收藏
页码:1524 / 1533
页数:10
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