The DNA-damage response in human biology and disease

被引：4518

作者：

Jackson, Stephen P. ^{[1
,2
]}

Bartek, Jiri ^{[3
,4
]}

机构：

[1] Univ Cambridge, Gurdon Inst, Cambridge CB2 1QN, England

[2] Univ Cambridge, Dept Biochem, Cambridge CB2 1QN, England

[3] Danish Canc Soc, Ctr Genotox Stress Res, DK-2100 Copenhagen, Denmark

[4] Inst Mol Genet, CZ-14220 Prague, Czech Republic

来源：

NATURE | 2009年 / 461卷 / 7267期

基金：

英国惠康基金; 新加坡国家研究基金会; 英国生物技术与生命科学研究理事会;

关键词：

DOUBLE-STRAND BREAKS; HEMATOPOIETIC STEM-CELLS; CELLULAR SENESCENCE; HOMOLOGOUS RECOMBINATION; REPAIR PATHWAYS; EXCISION-REPAIR; CANCER; GENOME; ATM; P53;

D O I：

10.1038/nature08467

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The prime objective for every life form is to deliver its genetic material, intact and unchanged, to the next generation. This must be achieved despite constant assaults by endogenous and environmental agents on the DNA. To counter this threat, life has evolved several systems to detect DNA damage, signal its presence and mediate its repair. Such responses, which have an impact on a wide range of cellular events, are biologically significant because they prevent diverse human diseases. Our improving understanding of DNA-damage responses is providing new avenues for disease management.

引用

页码：1071 / 1078

页数：8

共 101 条

[31] DNA repair pathways as targets for cancer therapy [J].