Relevance of Na,K-ATPase to local extracellular potassium homeostasis and modulation of synaptic transmission

被引：56
|
作者：
Gloor, SM
机构：
[1] Biochemistry II, Swiss Fed. Institute of Technology, ETH Center
来源：
FEBS LETTERS | 1997年 / 412卷 / 01期
关键词：
Na; K-ATPase; regulation; ionic homeostasis; nervous system;
D O I：
10.1016/S0014-5793(97)00774-6
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The ion gradients generated by the Na,K-ATPase are essential for Na+-coupled transport systems, osmoregulation and restoration of ion concentrations in excitable tissues. Indirectly, the sodium pump controls intracellular Ca2+ concentration through the Na/Ca exchanger. In the nervous system various neurotransmitters can modulate Na,K-ATPase activity. The great diversity of Na,K-ATPase subunit isoforms, their complex spatial and temporal regulation of expression and their cellular localisation imply a functional role of the sodium pump in different regulatory pathways. Among these, potassium homeostasis and modulation of synaptic transmission are discussed here. (C) 1997 Federation of European Biochemical Societies.
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页码：1 / 4
页数：4
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