Additional antiprotozoal flavonol glycosides of the aerial parts of Helianthemum glomeratum

被引：27

作者：

Calzada, Fernando ^{[1
]}

Alanis, Alma Delia ^{[1
]}

机构：

[1] Hosp Pediat Mexico City, Unidad Invest Med & Farmacol Prod Nat, Ctr Med Nacl Siglo 21, IMSS, Mexico City 06725, DF, Mexico

来源：

PHYTOTHERAPY RESEARCH | 2007年 / 21卷 / 01期

关键词：

Helianthemum glomeratum; flavonol glycosides; antiprotozoal activity; Entamoeba histolytica; Giardia lamblia;

D O I：

10.1002/ptr.2031

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Bioassay-guided fractionation of the methanol extract of aerial parts from Helianthemum glomeratum afforded five antiprotozoal flavonol glycosides: tiliroside, kaempferol-3-O-(3",6"di-O-E-p-coumaroyl)-beta-glucopyranoside, astragalin, quercitrin and isoquercitrin. The in vitro antiprotozoal assay showed that tiliroside was the most potent antiamoebic and antigiardial compound with IC50 values of 17.5 mu g/mL for Entamoeba histolytica and 17.4 mu g/mL for G. lamblia. Isoquercitrin showed selectivity against E. histolytica (IC50 14.7 mu g/mL) and quercitrin toward G. lamblia (IC50 24.3 mu g/mL). All isolated compounds were less active than metronidazole and emetine, two antiprotozoal drugs used as positive controls. Copyright (c) 2006 John Wiley & Sons, Ltd.

引用

页码：78 / 80

页数：3