Efficient synthesis of nevirapine analogs to study its metabolic profile by click fishing

被引：7

作者：

Bernard, Sylvain ^{[1
]}

Defoy, Daniel ^{[2
]}

Dory, Yves L. ^{[1
]}

Klarskov, Klaus ^{[2
]}

机构：

[1] Univ Sherbrooke, Dept Chim, Inst Pharmacol Sherbrooke, Sherbrooke, PQ J1H 5N4, Canada

[2] Univ Sherbrooke, Dept Pharmacol, Inst Pharmacol Sherbrooke, Sherbrooke, PQ J1H 5N4, Canada

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2009年 / 19卷 / 21期

基金：

加拿大自然科学与工程研究理事会;

关键词：

Nevirapine; Synthesis; 5-Exo-dig cyclization; Click coupling; INDUCED SKIN RASH; REVERSE-TRANSCRIPTASE; CYCLOADDITION; INHIBITORS; CHEMISTRY;

D O I：

10.1016/j.bmcl.2009.09.011

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Knowledge of the biotransformation and pharmacokinetics of the antiretroviral agent nevirapine is still insufficient. In order to trace rash inducing metabolites of nevirapine, we devised a short and efficient multi-gram synthesis of a nevirapine analog that can be coupled to azide containing compounds by click chemistry. (c) 2009 Elsevier Ltd. All rights reserved.

引用

页码：6127 / 6130

页数：4

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