The macrophage foam cell as a target for therapeutic intervention

被引：586

作者：

Li, AC

Glass, CK ^{[1
]}

机构：

[1] Univ Calif San Diego, Dept Cellular & Mol Med, La Jolla, CA 92093 USA

[2] Univ Calif San Diego, Dept Med, La Jolla, CA 92093 USA

来源：

NATURE MEDICINE | 2002年 / 8卷 / 11期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/nm1102-1235

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Specialized functions of macrophages have evolved to protect the body from infection. However, the same mechanisms that enable phagocytosis of pathogens and activation of leukocytes also permit the uptake of lipoproteins and release of reactive oxygen species and immune mediators that collectively contribute to atherosclerosis. New approaches to inhibit lipid accumulation in macrophage foam cells and reduce inflammatory responses may be of therapeutic value in preventing coronary artery disease.

引用

收藏

页码：1235 / 1242

页数：8

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