Cortical kindling induces elevated levels of AMPA and GABA receptor subunit mRNA within the amygdala/piriform region and is associated with behavioral changes in the rat

被引：4

作者：

Henderson, Amy K. ^{[1
]}

Galic, Michael A. ^{[2
]}

Teskey, G. Campbell ^{[1
,3
]}

机构：

[1] Univ Calgary, Dept Psychol, Calgary, AB T2N 1N4, Canada

[2] Univ Calgary, Dept Neurosci, Calgary, AB T2N 1N4, Canada

[3] Univ Calgary, Dept Cell Biol & Anat, Calgary, AB T2N 1N4, Canada

来源：

EPILEPSY & BEHAVIOR | 2009年 / 16卷 / 03期

基金：

加拿大自然科学与工程研究理事会; 加拿大健康研究院;

关键词：

Seizures; Kindling; Epilepsy; Rat; Receptor; Anxiety; Comorbidity; TEMPORAL-LOBE EPILEPSY; LONG-TERM POTENTIATION; PLUS-MAZE; INTERICTAL EMOTIONALITY; SYNAPTIC PLASTICITY; OBJECT RECOGNITION; PERIRHINAL CORTEX; NMDA RECEPTORS; SPATIAL MEMORY; SEIZURE-PRONE;

D O I：

10.1016/j.yebeh.2009.08.015

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Cortical kindling causes alterations within the motor cortex and results in long-standing motor deficits. Less attention has been directed to other regions that also participate in the epileptiform activity. We examined if cortical kindling Could induce changes in excitatory and inhibitory receptor subunit mRNA in the amygdala/piriform regions and if such changes are associated with behavioral deficits. After cortical kindling, amygdala/piriform regions were dissected to analyze mRNA levels of NMDA, AMPA, and GABA receptor Subunits using reverse transcription polymerase chain reaction, or rats were subjected to a series of behavioral tests. Kindled rats had significantly greater amounts of GluR1 and GluR2 AMPA receptor mRNA, and alpha 1 and alpha 2 GABA receptor subunit mRNA, compared with sham controls, which was associated with greater anxiety-like behaviors in the elevated plus maze and reduced freezing behaviors in the fear conditioning task. In Summary, cortical kindling produces dynamic receptor subunit changes in regions in addition to the seizure focus. (C) 2009 Elsevier Inc. All rights reserved.

引用

页码：404 / 410

页数：7