Genome-nuclear lamina interactions: from cell populations to single cells

被引：24

作者：

Yanez-Cuna, J. Omar ^{[1
]}

van Steensel, Bas ^{[1
,2
]}

机构：

[1] Netherlands Canc Inst, Div Gene Regulat, Plesmanlaan 121, NL-1066 CX Amsterdam, Netherlands

[2] Erasmus Univ, Med Ctr, Dept Cell Biol, Rotterdam, Netherlands

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 2017年 / 43卷

基金：

欧洲研究理事会;

关键词：

EMBRYONIC STEM-CELLS; DOMAIN ORGANIZATION; CHROMATIN STATE; HETEROCHROMATIN; PERIPHERY; SEQUENCE; GENES; DIFFERENTIATION; TRANSCRIPTION; ASSOCIATION;

D O I：

10.1016/j.gde.2016.12.005

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Lamina-associated domains (LADs) are large genomic regions that interact with the nuclear lamina (NL) and help to guide the spatial folding of chromosomes in the interphase nucleus. LADs have been linked to gene repression and other functions. Recent studies have begun to uncover some of the molecular players that drive LAD-NL interactions. A picture emerges in which DNA sequence, chromatin components and nuclear lamina proteins play an important role. Complementary to this, imaging and single-cell genomics approaches have revealed that some LAD-NL interactions are variable from cell to cell, while others are very stable. Understanding LADs can provide a unique perspective into the general process of genome organization.

引用

页码：67 / 72

页数：6

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