Dose-reduced conditioning regimen followed by allogeneic stem cell transplantation in patients with myelofibrosis with myeloid metaplasia

Three patients with myelofibrosis received allogeneic stem cell transplantation after a dose- reduced conditioning regimen of busulphan ( 8 mg/ kg), fludarabine (180 mg/m(2)) and antithymocyte globulin (4 x 10 mg/ kg). The median age at transplantation was 51 years ( range 44 - 58). All patients engrafted with a leucocyte count > 1.0 x 10(9)/I after a median of 18 d ( range 16 - 20). Grade II acute skin graft- versus- host disease ( GvHD) occurred in one patient. One limited and one extensive chronic GvHD was observed. All patients achieved complete haematological remission. In one patient the fibrosis resolved completely 180 d post transplant. All patients are alive 126, 466 and 764 d after transplantation.