Ensemble of Heterogeneous Flexible Neural Tree for the Approximation and Feature-Selection of Poly (Lactic-co-glycolic Acid) Micro- and Nanoparticle

In this work, we used an adaptive feature-selection and function approximation model, called, flexible neural tree (FNT) for predicting Poly (lactic-co-glycolic acid) (PLGA) micro-and nanoparticle's dissolution-rates that bears significant role in the pharmaceutical, medical, and drug manufacturing industries. Several factor influences PLGA nanoparticles dissolution-rate prediction. FNT model enable us to deal with feature-selection and prediction simultaneously. However, a single FNT model may or may not offer a generalized solution. Hence, to build a generalized model, we used an ensemble of FNTs. In this work, we have provided a comprehensive study for examining the most significant (influencing) features that influences dissolution rate prediction.