Usefulness of intravenous granisetron for prevention of neurally mediated hypotension upon head upright tilt testing

被引：13

作者：

Tsikouris, JP

Kluger, J

Chow, MSS

White, CM

机构：

[1] Hartford Hosp, Drug Informat Ctr, Dept Pharm, Hartford, CT 06102 USA

[2] Hartford Hosp, Div Cardiol, Hartford, CT 06102 USA

[3] Univ Connecticut, Sch Pharm, Storrs, CT USA

[4] Univ Connecticut, Sch Med, Farmington, CT USA

[5] Chinese Univ Hong Kong, Shatin, Hong Kong, Peoples R China

来源：

AMERICAN JOURNAL OF CARDIOLOGY | 2000年 / 85卷 / 10期

关键词：

D O I：

10.1016/S0002-9149(00)00743-8

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The serotonergic system has been implicated in the pathophysiology of neurally mediated hypotension. The present pilot study suggests that 5-HT3 receptor antagonism with granisetron attenuates the early sympathetic component of neurally mediated syncope, and may contribute to the abolishment of syncope or presyncope upon head-up tilt testing.

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页码：1262 / +

页数：5

相关论文

共 19 条

[1] PROVOCATION OF BRADYCARDIA AND HYPOTENSION BY ISOPROTERENOL AND UPRIGHT POSTURE IN PATIENTS WITH UNEXPLAINED SYNCOPE [J].

ALMQUIST, A ;

GOLDENBERG, IF ;

MILSTEIN, S ;

CHEN, MY ;

CHEN, XC ;

HANSEN, R ;

GORNICK, CC ;

BENDITT, DG .

NEW ENGLAND JOURNAL OF MEDICINE, 1989, 320 (06) :346-351

[2] Single-blind study of the effects of intravenous dolasetron mesylate versus ondansetron on electrocardiographic parameters in normal volunteers [J].

Benedict, CR ;

Arbogast, R ;

Martin, L ;

Patton, L ;

Morrill, B ;

Hahne, W .

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, 1996, 28 (01) :53-59

[3] PROPOSALS FOR THE CLASSIFICATION AND NOMENCLATURE OF FUNCTIONAL RECEPTORS FOR 5-HYDROXYTRYPTAMINE [J].

BRADLEY, PB ;

ENGEL, G ;

FENIUK, W ;

FOZARD, JR ;

HUMPHREY, PPA ;

MIDDLEMISS, DN ;

MYLECHARANE, EJ ;

RICHARDSON, BP ;

SAXENA, PR .

NEUROPHARMACOLOGY, 1986, 25 (06) :563-576

[4] COMPARISON OF RESPONSES TO ISOPROTERENOL AND EPINEPHRINE DURING HEAD-UP TILT IN SUSPECTED VASODEPRESSOR SYNCOPE [J].

CALKINS, H ;

KADISH, A ;

SOUSA, J ;

ROSENHECK, S ;

MORADY, F .

AMERICAN JOURNAL OF CARDIOLOGY, 1991, 67 (02) :207-209

[5] Effects of paroxetine hydrochloride, a selective serotonin reuptake inhibitor, on refractory vasovagal syncope: A randomized, double-blind, placebo-controlled study [J].

Di Girolamo, E ;

Di Iorio, C ;

Sabatini, P ;

Leonzio, L ;

Barbone, C ;

Barsotti, A .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 1999, 33 (05) :1227-1230

[6] REPRODUCIBILITY OF HEAD UPRIGHT TILT TABLE TEST-RESULTS IN PATIENTS WITH SYNCOPE [J].

GRUBB, BP ;

WOLFE, D ;

TEMESYARMOS, P ;

HAHN, H ;

ELLIOTT, L .

PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY, 1992, 15 (10) :1477-1481

[7] USE OF SERTRALINE HYDROCHLORIDE IN THE TREATMENT OF REFRACTORY NEUROCARDIOGENIC SYNCOPE IN CHILDREN AND ADOLESCENTS [J].

GRUBB, BP ;

SAMOIL, D ;

KOSINSKI, D ;

KIP, K ;

BREWSTER, P .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 1994, 24 (02) :490-494

[8] USEFULNESS OF FLUOXETINE HYDROCHLORIDE FOR PREVENTION OF RESISTANT UPRIGHT TILT INDUCED SYNCOPE [J].

GRUBB, BP ;

WOLFE, DA ;

SAMOIL, D ;

TEMESYARMOS, P ;

HAHN, H ;

ELLIOTT, L .

PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY, 1993, 16 (03) :458-464

[9]

Kalkman HO, 1984, J HYPERTENS, V2, P143

[10]

KENNY RA, 1986, LANCET, V1, P1352