ZBP-89 reduces the cell death threshold in hepatocellular carcinoma cells by increasing caspase-6 and S phase cell cycle arrest

被引：18

作者：

Chen, George G. ^{[1
]}

Chan, Ursula P. F. ^{[1
]}

Bai, Long-Chuan ^{[2
]}

Fung, King Yip ^{[1
]}

Tessier, Art ^{[2
]}

To, Ann K. Y. ^{[1
]}

Merchant, Juanita L. ^{[2
]}

Lai, Paul B. S. ^{[1
]}

机构：

[1] Chinese Univ Hong Kong, Dept Surg, Prince Wales Hosp, Shatin, Hong Kong, Peoples R China

[2] Univ Michigan, Ann Arbor, MI 48109 USA

来源：

CANCER LETTERS | 2009年 / 283卷 / 01期

关键词：

Caspase-6; Cell cycle; Hepatocellular carcinoma; p53; Proliferation; ZBP-89; TRANSCRIPTION FACTOR ZBP-89; GENE-TRANSCRIPTION; P53; GENE; APOPTOSIS; EXPRESSION; REPRESSOR; IDENTIFICATION; CISPLATIN; MUTATION; PATHWAY;

D O I：

10.1016/j.canlet.2009.03.024

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

ZBP-89 inhibits the some tumor cells but its role in HCC is unknown. We investigated effect of ZBP-89 on cell death of 5 HCC cell lines with different status of p53. We found that ZBP-89 significantly induced cell death of all HCC cells particularly those with wild-type p53. The inhibition was well correlated with the induction of caspase-6 activity. The inhibition of caspase-6 abolished the effect of ZBP-89. ZBP-89 reduced the cells in G2-M but increased them in S phase. With the changes in caspase-6 and cell cycle, ZBP-89 greatly enhanced the killing effectiveness of 5-fluorouracil or staurosporine in HCC cells. (C) 2009 Elsevier Ireland Ltd. All rights reserved.

引用

页码：52 / 58

页数：7

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