Microglia roles in synaptic plasticity and myelination in homeostatic conditions and neurodevelopmental disorders

被引：80

作者：

Bar, Ela ^{[1
,2
,3
]}

Barak, Boaz ^{[1
,2
]}

机构：

[1] Tel Aviv Univ, Sch Psychol Sci, Fac Social Sci, IL-69978 Tel Aviv, Israel

[2] Tel Aviv Univ, Sagol Sch Neurosci, IL-69978 Tel Aviv, Israel

[3] Tel Aviv Univ, Fac Life Sci, Sch Neurobiol Biochem & Biophys, Tel Aviv, Israel

来源：

GLIA | 2019年 / 67卷 / 11期

关键词：

autism; microglia; myelin; neurodevelopmental disorders; synaptic plasticity; CENTRAL-NERVOUS-SYSTEM; DORSOLATERAL PREFRONTAL CORTEX; OLIGODENDROCYTE LINEAGE CELLS; TOLL-LIKE RECEPTORS; BRAIN-DEVELOPMENT; MOUSE MODEL; VAL66MET POLYMORPHISM; MULTIPLE-SCLEROSIS; CLEARANCE FUNCTION; DOWN-REGULATION;

D O I：

10.1002/glia.23637

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Microglia are the immune cells of the brain, involved in synapse formation, circuit sculpting, myelination, plasticity, and cognition. Being active players during early development as well as in adulthood, microglia affect other cells directly by their long processes and unique receptors and indirectly by secreting growth factors and cytokines. In this review, we discuss the roles of microglia in neurodevelopmental disorders, synaptic plasticity, myelination, and homeostatic conditions throughout human and mouse development. Within these processes, we specifically focus on the contribution of altered microglial interactions with neurons and oligodendrocytes, altered cytokine and growth factor activities, and alterations in the complement system. We conclude by highlighting future perspectives and providing an overview of future research on microglia.

引用

页码：2125 / 2141

页数：17

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