c-Fos expression in the mouse brainstem after unilateral labyrinthectomy

被引:2
作者
Tsuji, Jun [1 ]
Murai, Norihiko [1 ]
Naito, Yasushi [1 ]
Ito, Juichi [1 ]
机构
[1] Kyoto Univ, Grad Sch Med, Dept Otolaryngol Head & Neck Surg, Kyoto, Japan
关键词
unilateral vestibular disturbance; vestibular compensation; c-Fos; mice;
D O I
10.1080/03655230601065175
中图分类号
R76 [耳鼻咽喉科学];
学科分类号
100213 ;
摘要
Conclusion. The results indicated that the vestibular, prepositus hypoglossal, and inferior olive nuclei were activated after unilateral labyrinthectomy in mice like in other species. It is expected that the application of the present procedure to appropriate gene-deficient mice will elucidate the mechanism of the process of vestibular compensation. Objective. Vestibular compensation is attributed to functional and structural reorganization of neural networks in the central vestibular system, but its precise mechanism is still not clear. c-Fos protein is used as a marker of neuronal activation, because of its very limited expression in the normal state and rapid appearance after external stimulation. Previous reports, investigating c-Fos expression after unilateral labyrinthectomy were made in rats and guinea pigs, but not in the mouse brainstem. Materials and methods. For future application to the gene knockout mouse, we examined c-Fos expression in the mouse after unilateral labyrinthectomy. Results. Twenty-four hours after surgery, significantly increased c-Fos positive cells were observed in the bilateral medial vestibular nucleus (MVe), bilateral spinal vestibular nucleus (SpVe), contralateral prepositus hypoglossal nucleus (PrH), and contralateral inferior olive nucleus (IO).
引用
收藏
页码:8 / 11
页数:4
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