Enhancing antitumor activity of silver nanoparticles by modification with cell-penetrating peptides

被引：43

作者：

Farkhani, Samad Mussa ^{[1
,2
,3
]}

Fard, Abbas Asoudeh ^{[1
,2
]}

Zakeri-Milani, Parvin ^{[4
,5
]}

Mojarrad, Javid Shahbazi ^{[6
,7
]}

Valizadeh, Hadi ^{[1
,7
,8
]}

机构：

[1] Tabriz Univ Med Sci, Fac Adv Med Sci, Res Ctr Pharmaceut Nanotechnol, Tabriz, Iran

[2] Tabriz Univ Med Sci, Fac Adv Med Sci, Dept Med Nanotechnol, Tabriz, Iran

[3] Tabriz Univ Med Sci, Student Res Comm, Tabriz, Iran

[4] Tabriz Univ Med Sci, Liver & Gastrointestinal Dis Res Ctr, Tabriz, Iran

[5] Tabriz Univ Med Sci, Fac Pharm, Tabriz, Iran

[6] Tabriz Univ Med Sci, Biotechnol Res Ctr, Tabriz, Iran

[7] Tabriz Univ Med Sci, Fac Pharm, Tabriz, Iran

[8] Tabriz Univ Med Sci, Drug Appl Res Ctr, Tabriz, Iran

来源：

ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY | 2017年 / 45卷 / 05期

关键词：

Anticancer; cell-penetrating peptides; cytotoxicity; silver nanoparticles; GOLD NANOPARTICLES; CANCER-TREATMENT; QUANTUM DOTS; DELIVERY; TRYPTOPHAN; THERAPY; MODEL;

D O I：

10.1080/21691401.2016.1200059

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Recently, silver nanoparticles (AgNPs) have been used for cancer treatment. To achieve a successful anti-cancer activity, AgNP needs to be delivered sufficiently to the cells. Cell-penetrating peptides (CPPs) are small cationic peptides that have ability to transport various cargos across cell membranes. In this study, a strategy was developed for cancer treatment, where AgNP modified with CPPs displayed dramatically antitumor activity in MCF-7 cell lines. Peptides-modified AgNPs showed significant enhancement in killing tumor cells by increasing the uptake of AgNP into cell lines and could be a new class of nano-drug for cancer treatment.

引用

页码：1029 / 1035

页数：7

共 34 条

[1] Cytotoxicity and Genotoxicity of Silver Nanoparticles in Human Cells [J].