Evidence for the importance of the human dopamine transporter gene for withdrawal symptomatology of alcoholics in a German population

被引：31
作者：
Wernicke, C
Smolka, M
Gallinat, J
Winterer, G
Schmidt, LG
Rommelspacher, H
机构：
[1] Free Univ Berlin, Benjamin Franklin Med Sch, Dept Clin Neurobiol, D-14050 Berlin, Germany
[2] Univ Mainz, Dept Psychiat, D-55131 Mainz, Germany
[3] NIMH, Clin Brain Disorder Branch, Bethesda, MD 20892 USA
[4] Free Univ Berlin, Benjamin Franklin Med Sch, Dept Psychiat, D-14050 Berlin, Germany
来源：
NEUROSCIENCE LETTERS | 2002年 / 333卷 / 01期
关键词：
alcoholism; dopamine transporter; 3 ' untranslated region; withdrawal;
D O I：
10.1016/S0304-3940(02)00985-0
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Two new polymorphisms in the 3' untranslated region (3'UTR) of the dopamine transporter (DAT1) gene, adjacent to the known variable number of tandem repeats (VNTR) polymorphism, have been investigated in the present population-based association study including 351 alcoholics and 336 controls. The Dral restriction site was not polymorphic in our population. The G2319A polymorphism was not significantly different with respect to genotype or allele distribution between alcoholics and controls. Subsequently, in individuals with VNTR homozygosity for the ten repeat allele, we found a higher prevalence of A/A homozygosity in patients with seizure history (P = 0.001, odds ratio (OR) = 7.913), with delirium history (P = 0.032, OR = 4.707), and with an alcoholic mother (P = 0.021, OR = 5.250), compared to homozygote 10/10 controls. Our findings provide further evidence that the 3'UTR of the DAT1 gene affects vulnerability to severe alcohol withdrawal. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.
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收藏
页码：45 / 48
页数：4
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