Prenylated phenylpropanoid compounds from the stem bark of Illicium burmanicum

被引：11

作者：

Huang, Doudou ^{[1
]}

Zhu, Haiying ^{[3
]}

Chen, Yanhong ^{[1
]}

Chen, Wansheng ^{[2
]}

Xue, Dan ^{[1
]}

Sun, Lianna ^{[1
]}

机构：

[1] Second Mil Med Univ, Sch Pharm, Dept Pharmacognosy, Shanghai 200433, Peoples R China

[2] Second Mil Med Univ, Changzheng Hosp, Shanghai 200003, Peoples R China

[3] Second Mil Med Univ, Dept Cell Biol, Shanghai 200433, Peoples R China

来源：

FITOTERAPIA | 2015年 / 107卷

关键词：

Illicium burmanicum; Prenylated phenylpropanoid compounds; Stem bark; NF-kappa B; C-6-C-3; COMPOUNDS; SESQUITERPENE; PHYTOQUINOIDS; CONSTITUENTS; GLYCOSIDES; FRUITS; PLANTS;

D O I：

10.1016/j.fitote.2015.09.009

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Ten new prenylated phenylpropanoid compounds, burmanicumols A-G (1-6) and illifrognones D-G (7-10), and seven known prenylated phenylpropanoid compounds, were isolated from the stem bark of Micium burmanicum. The structures of the new compounds were determined on the basis of 1D and 2D NMR, HRESIMS, and CD experiments. Compounds 3, 8, 10, and 14 were moderately potent inhibitors of the NF-kappa B pathway, with IC50 values ranging from 10.31 to 35.16 mu g/mL tripterygium glycosides and pavlin were used as the positive controls. (C) 2015 Elsevier B.V. All reserved.

引用

页码：22 / 28

页数：7

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