A systematic mRNA control mechanism for germline stem cell homeostasis and cell fate specification

被引：6

作者：

Lee, Myon-Hee ^{[1
,4
]}

Mamillapalli, Srivalli Swathi ^{[1
]}

Keiper, Brett D. ^{[2
]}

Cha, Dong Seok ^{[3
]}

机构：

[1] E Carolina Univ, Brody Sch Med, Hematol Oncol Div, Dept Med, Greenville, NC 27834 USA

[2] E Carolina Univ, Brody Sch Med, Dept Biochem & Mol Biol, Greenville, NC 27834 USA

[3] Woosuk Univ, Dept Oriental Pharm, Coll Pharm, Jeonju 55338, South Korea

[4] Univ N Carolina, Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27599 USA

来源：

BMB REPORTS | 2016年 / 49卷 / 02期

关键词：

Germline stem cells; Cell fate specification; Caenorhabditis elegans; mRNA selection; Translational control; CAENORHABDITIS-ELEGANS GERMLINE; CYTOPLASMIC POLY(A) POLYMERASE; C-ELEGANS; SEX-DETERMINATION; BINDING PROTEIN; GENES; SPERM; TRANSLATION; MEIOSIS; GLP-1;

D O I：

10.5483/BMBRep.2016.49.2.135

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Germline stem cells (GSCs) are the best understood adult stem cell types in the nematode Caenorhabditis elegans, and have provided an important model system for studying stem cells and their cell fate in vivo, in mammals. In this review, we propose a mechanism that controls GSCs and their cell fate through selective activation, repression and mobilization of the specific mRNAs. This mechanism is acutely controlled by known signal transduction pathways (e.g., Notch signaling and Ras-ERK MAPK signaling pathways) and P granule (analogous to mammalian germ granule)-associated mRNA regulators (FBF-1, FBF-2, GLD-1, GLD-2, GLD-3, RNP-8 and IFE-1). Importantly, all regulators are highly conserved in many multi-cellular animals. Therefore, GSCs from a simple animal may provide broad insight into vertebrate stem cells (e.g., hematopoietic stem cells) and their cell fate specification.

引用

页码：93 / 98

页数：6

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