Magnetically Activated Electroactive Microenvironments for Skeletal Muscle Tissue Regeneration

被引：55

作者：

Ribeiro, Sylvie ^{[1
,2
]}

Ribeiro, Clarisse ^{[1
,3
]}

Carvalho, Estela O. ^{[1
,3
]}

Tubio, Carmen R. ^{[4
]}

Castro, Nelson ^{[4
]}

Pereira, Nelson ^{[1
,5
]}

Correia, Vitor ^{[1
,5
]}

Gomes, Andreia C. ^{[2
]}

Lanceros-Mendez, Senentxu ^{[1
,4
,6
]}

机构：

[1] Univ Minho, Ctr Dept Fis, P-4710057 Braga, Portugal

[2] Univ Minho, Ctr Mol & Environm Biol CBMA, P-4710057 Braga, Portugal

[3] Univ Minho, CEB Ctr Biol Engn, P-4710057 Braga, Portugal

[4] Basque Ctr Mat Applicat & Nanostruct, BCMat, Leioa 48940, Spain

[5] Univ Minho, Ctr Algoritmi, Leioa 48940, Spain

[6] Basque Fdn Sci, IKERBASQUE, Bilbao 48013, Spain

来源：

ACS APPLIED BIO MATERIALS | 2020年 / 3卷 / 07期

关键词：

magnetoelectric biomaterials; muscle tissue engineering; mechanoelectrical stimuli; myotubes; bioreactors; POLY(VINYLIDENE FLUORIDE); OSTEOGENIC DIFFERENTIATION; SURFACE WETTABILITY; STIMULATION; CELLS; ROUGHNESS; MEMBRANES; ADHESION; PHASES; FILMS;

D O I：

10.1021/acsabm.0c00315

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

This work reports on magnetoelectric biomaterials suitable for effective proliferation and differentiation of myoblast in a biomimetic microenvironment providing the electromechanical stimuli associated with this tissue in the human body. Magnetoelectric films are obtained by solvent casting through the combination of a piezoelectric polymer, poly(vinylidene fluoride-trifluoro-ethylene), and magnetostrictive particles (CoFe2O4). The nonpoled and poled (with negative and positive surface charge) magnetoelectric composites are used to investigate their influence on C2C12 myoblast adhesion, proliferation, and differentiation. It is demonstrated that the proliferation and differentiation of the cells are enhanced by the application of mechanical and/or electrical stimulation, with higher values of maturation index under mechanoelectrical stimuli. These results show that magnetoelectric cell stimulation is a full potential approach for skeletal muscle tissue engineering applications.

引用

页码：4239 / 4252

页数：14

共 43 条

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