Mass Oral Azithromycin for Childhood Mortality: Timing of Death After Distribution in the MORDOR Trial

被引：15

作者：

Porco, Travis C. ^{[1
,2
,3
,4
]}

Hart, John ^{[5
]}

Arzika, Ahmed M. ^{[6
]}

Weaver, Jerusha ^{[7
]}

Kalua, Khumbo ^{[8
,9
]}

Mrango, Zakayo ^{[10
]}

Cotter, Sun Y. ^{[1
]}

Stoller, Nicole E. ^{[1
]}

O'Brien, Kieran S. ^{[1
]}

Fry, Dionna M. ^{[1
]}

Vanderschelden, Benjamin ^{[1
]}

Oldenburg, Catherine E. ^{[1
]}

West, Sheila K. ^{[7
]}

Bailey, Robin L. ^{[5
]}

Keenan, Jeremy D. ^{[1
,2
]}

Lietman, Thomas M. ^{[1
,2
,3
,4
]}

机构：

[1] Univ Calif San Francisco, Francis I Proctor Fdn, San Francisco, CA 94143 USA

[2] Univ Calif San Francisco, Dept Ophthalmol, San Francisco, CA 94143 USA

[3] Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA 94143 USA

[4] Univ Calif San Francisco, Inst Global Hlth Sci, San Francisco, CA 94143 USA

[5] London Sch Hyg & Trop Med, London, England

[6] Carter Ctr, Niamey, Niger

[7] Johns Hopkins Univ, Sch Med, Dana Ctr, Baltimore, MD USA

[8] Univ Malawi, Blantyre Inst Community Outreach, Blantyre, Malawi

[9] Univ Malawi, Coll Med, Blantyre, Malawi

[10] Natl Inst Med Res, Dar Es Salaam, Tanzania

来源：

CLINICAL INFECTIOUS DISEASES | 2019年 / 68卷 / 12期

基金：

比尔及梅琳达.盖茨基金会;

关键词：

childhood mortality; azithromycin; sub-Saharan Africa; TRACHOMA CONTROL; CHILDREN; MALARIA; IMPACT; RISK;

D O I：

10.1093/cid/ciy973

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In a large community-randomized trial, biannual azithromycin distributions significantly reduced postneonatal childhood mortality in sub-Saharan African sites. Here, we present a prespecified secondary analysis showing that much of the protective effect was in the first 3 months postdistribution. Distributing more frequently than biannually could be considered if logistically feasible.

引用

页码：2114 / 2116

页数：3

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