SLAMF1/CD150 in hematologic malignancies: Silent marker or active player?

被引：16
作者：
Gordiienko, Inna [1 ]
Shlapatska, Larysa [1 ]
Kovalevska, Larysa [1 ]
Sidorenko, Svetlana P. [1 ]
机构：
[1] Natl Acad Sci Ukraine, RE Kavetsky Inst Expt Pathol Oncol & Radiobiol, Dept Mol & Cellular Pathobiol, Kiev, Ukraine
来源：
CLINICAL IMMUNOLOGY | 2019年 / 204卷
关键词：
SLAMF1/CD150; Hematopoietic cells; Hematologic malignancies; Hodgkin's lymphoma; Chronic lymphocytic leukemia; LYMPHOCYTIC ACTIVATION MOLECULE; SLAM FAMILY RECEPTORS; HEALTH-ORGANIZATION CLASSIFICATION; CELL-SURFACE RECEPTORS; MEASLES-VIRUS; T-CELL; DIFFERENTIAL EXPRESSION; HODGKINS-DISEASE; MONOCLONAL-ANTIBODIES; CD150; SLAM;
D O I：
10.1016/j.clim.2018.10.015
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
SLAMF1/CD150 receptor is a founder of signaling lymphocyte activation molecule (SLAM) family of cell-surface receptors. It is widely expressed on cells within hematopoietic system. In hematologic malignancies CD150 cell surface expression is restricted to cutaneous T-cell lymphomas, few types of B-cell non-Hodgkin's lymphoma, near half of cases of chronic lymphocytic leukemia, Hodgkin's lymphoma, and multiple myeloma. Differential expression among various types of hematological malignancies allows considering CD150 as diagnostical and potential prognostic marker. Moreover, CD150 may be a target for antibody-based or measles virus oncolytic therapy. Due to CD150 signaling properties it is involved in regulation of malignant cell fate decision and tumor microenvironment in Hodgkin's lymphoma and chronic lymphocytic leukemia. This review summarizes evidence for the important role of CD150 in pathogenesis of hematologic malignancies.
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收藏
页码：14 / 22
页数：9
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