Endoglin moves and shapes endothelial cells

被引：15

作者：

Bautch, Victoria L. ^{[1
,2
]}

机构：

[1] Univ North Carolina Chapel Hill, Dept Biol, Chapel Hill, NC 27599 USA

[2] Univ North Carolina Chapel Hill, McAllister Heart Inst, Chapel Hill, NC 27599 USA

来源：

NATURE CELL BIOLOGY | 2017年 / 19卷 / 06期

关键词：

HEREDITARY HEMORRHAGIC TELANGIECTASIA; ANGIOGENESIS;

D O I：

10.1038/ncb3543

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Vascular malformations result from improper blood vessel responses to molecular and mechanical signals. Two studies now show that endothelial cell migration and cell shape changes are perturbed in mutants lacking the TGF beta/BMP co-receptor endoglin, leading to arteriovenous shunts. Endoglin coordinates endothelial cell responses to ligand-receptor signalling and flow-mediated mechanical cues.

引用

页码：593 / 595

页数：4

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