A highly Li+-selective glass optode based on fluorescence ratiometry

被引:31
作者
Ando, Yosuke [1 ]
Hiruta, Yuki [1 ]
Citterio, Daniel [1 ]
Suzuki, Koji [1 ]
机构
[1] Keio Univ, Dept Appl Chem, Fac Sci & Technol, Kohoku Ku, Kanagawa 2238522, Japan
基金
日本学术振兴会;
关键词
BULK OPTODES; CHARGE-TRANSFER; ION; LITHIUM; DESIGN; PH; SENSORS; DERIVATIVES; CHROMOPHORE; ELECTRODES;
D O I
10.1039/b912756a
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
This paper presents the preparation and characterization of a single-excitation, dual-emission ratiometric optical Li+-sensing device using a newly designed and synthesized highly Li+-selective fluoroionophore (KBL-01) carrying 14-crown-4 ether with tetramethyl and benzene blocking subunits as Li+-binding site and boron-dipyrromethene as fluorophore. The indicator dye was covalently immobilized on the surface of a porous glass support having a large internal surface area using a silane-coupling agent. The resulting Li+-selective glass optode shows dual fluorescence emission response in pseudo-serum at varying Li+ concentrations, allowing ratiometric signal processing. The obtained signal is independent of the presence of possibly interfering cations (Na+, K+, Mg-2+ and Ca2+) and pH. The sensor response was found to be reversible within the Li+ concentration range from 10(-4) to 10(-1) M, and showed good repeatability and light stability. The plots of the ratiometric signal versus the Li+ concentrations in spiked real human serum go along with the response curve in pseudo-serum. These results indicate that the novel Li+-selective glass optode can be employed as a Li+-sensing device with high durability, sensitivity and accuracy for medical analyses.
引用
收藏
页码:2314 / 2319
页数:6
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