Meta-Analysis of Genome-wide Association Studies with Overlapping Subjects

被引：116

作者：

Lin, Dan-Yu ^{[1
]}

Sullivan, Patrick F. ^{[2
]}

机构：

[1] Univ N Carolina, Dept Biostat, Chapel Hill, NC 27599 USA

[2] Univ N Carolina, Dept Genet, Chapel Hill, NC 27599 USA

来源：

AMERICAN JOURNAL OF HUMAN GENETICS | 2009年 / 85卷 / 06期

关键词：

LOCI; SCHIZOPHRENIA; REPLICATION; VARIANTS; DISEASES;

D O I：

10.1016/j.ajhg.2009.11.001

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Data from multiple genome-wide association studies are often analyzed together for the purposes of combining information from several studies of the same disease or comparing results across different disorders. We provide a valid and efficient approach to such meta-analysis, allowing for overlapping study subjects. The available data may contain individual participant records or only meta-analytic summary results. Simulation studies demonstrate that failure to account for overlapping subjects can greatly inflate type I error when combining results from multiple studies of the same disease and can drastically reduce power when comparing results across different disorders. In addition, the proposed approach can be substantially more powerful than the simple approach of splitting the overlapping subjects among studies, especially for comparing results across different disorders. The advantages of the new approach are illustrated with empirical data from two sets of genome-wide association studies.

引用

页码：862 / 872

页数：11

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