Nivolumab maintenance in high-risk acute myeloid leukemia patients: a single-arm, open-label, phase II study

被引：31
作者：
Reville, Patrick K. [1 ]
Kantarjian, Hagop M. [2 ]
Ravandi, Farhad [2 ]
Jabbour, Elias [2 ]
DiNardo, Courtney D. [2 ]
Daver, Naval [2 ]
Pemmaraju, Naveen [2 ]
Ohanian, Maro [2 ]
Alvarado, Yesid [2 ]
Xiao, Lianchun [3 ]
Alatrash, Gheath [4 ]
Loghavi, Sanam [5 ]
Rausch, Caitlin R. [6 ]
Borthakur, Gautam [2 ]
Konopleva, Marina [2 ]
Cortes, Jorge [7 ]
Kadia, Tapan M. [2 ]
机构：
[1] Univ Texas MD Anderson Canc Ctr, Div Canc Med, 1400 Holcombe Blvd, Houston, TX 77030 USA
[2] Univ Texas MD Anderson Canc Ctr, Dept Leukemia, 1400 Holcombe Blvd, Houston, TX 77030 USA
[3] Univ Texas MD Anderson Canc Ctr, Dept Biostat, 1400 Holcombe Blvd, Houston, TX 77030 USA
[4] Univ Texas MD Anderson Canc Ctr, Dept Stem Cell Transplantat & Cellular Therapy, 1400 Holcombe Blvd, Houston, TX 77030 USA
[5] Univ Texas MD Anderson Canc Ctr, Dept Hematopathol, 1400 Holcombe Blvd, Houston, TX 77030 USA
[6] Univ Texas MD Anderson Canc Ctr, Div Pharm, 1400 Holcombe Blvd, Houston, TX 77030 USA
[7] Augusta Univ, Georgia Canc Ctr, 1411 Laney Walker Blvd, Augusta, GA USA
来源：
BLOOD CANCER JOURNAL | 2021年 / 11卷 / 03期
关键词：
TRANSPLANTATION;
D O I：
10.1038/s41408-021-00453-z
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
引用
收藏
页数：5
相关论文
共 13 条
  • [1] Almeida Antonio M, 2016, Leuk Res Rep, V6, P1, DOI 10.1016/j.lrr.2016.06.001
  • [2] Efficacy, Safety, and Biomarkers of Response to Azacitidine and Nivolumab in Relapsed/Refractory Acute Myeloid Leukemia: A Nonrandomized, Open-Label, Phase II Study
    Daver, Naval
    Garcia-Manero, Guillermo
    Basu, Sreyashi
    Boddu, Prajwal C.
    Alfayez, Mansour
    Cortes, Jorge E.
    Konopleva, Marina
    Ravandi-Kashani, Farhad
    Jabbour, Elias
    Kadia, Tapan
    Nogueras-Gonzalez, Graciela M.
    Ning, Jing
    Pemmaraju, Naveen
    DiNardo, Courtney D.
    Andreeff, Michael
    Pierce, Sherry A.
    Gordon, Tauna
    Kornblau, Steven M.
    Flores, Wilmer
    Alhamal, Zainab
    Bueso-Ramos, Carlos
    Jorgensen, Jeffrey L.
    Patel, Keyur P.
    Blando, Jorge
    Allison, James P.
    Sharma, Padmanee
    Kantarjian, Hagop
    [J]. CANCER DISCOVERY, 2019, 9 (03) : 370 - 383
  • [3] HLA Match Likelihoods for Hematopoietic Stem-Cell Grafts in the US Registry
    Gragert, Loren
    Eapen, Mary
    Williams, Eric
    Freeman, John
    Spellman, Stephen
    Baitty, Robert
    Hartzman, Robert
    Rizzo, J. Douglas
    Horowitz, Mary
    Confer, Dennis
    Maiers, Martin
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2014, 371 (04) : 339 - 348
  • [4] HOROWITZ MM, 1990, BLOOD, V75, P555
  • [5] Azacitidine maintenance after intensive chemotherapy improves DFS in older AML patients
    Huls, Gerwin
    Chitu, Dana A.
    Havelange, Violaine
    Jongen-Lavrencic, Mojca
    van de Loosdrecht, Arjan A.
    Biemond, Bart J.
    Sinnige, Harm
    Hodossy, Beata
    Graux, Carlos
    Kooy, Rien van Marwijk
    de Weerdt, Okke
    Breems, Dimitri
    Klein, Saskia
    Kuball, Jurgen
    Deeren, Dries
    Terpstra, Wim
    Vekemans, Marie-Christiane
    Ossenkoppele, Gert J.
    Vellenga, Edo
    Lowenberg, Bob
    Breems, D. A.
    Verhoef, G.
    Schuermans, C.
    Terpstra, J.
    Van Esser, J. W. J.
    van Lammeren-Venema, D.
    Legdeur, M. C. J. C.
    Jie, G. K. S.
    van der Velden, W.
    Lowenberg, B.
    [J]. BLOOD, 2019, 133 (13) : 1457 - 1464
  • [6] Allogeneic Stem Cell Transplantation for Acute Myeloid Leukemia in First Complete Remission Systematic Review and Meta-analysis of Prospective Clinical Trials
    Koreth, John
    Schlenk, Richard
    Kopecky, Kenneth J.
    Honda, Sumihisa
    Sierra, Jorge
    Djulbegovic, Benjamin J.
    Wadleigh, Martha
    DeAngelo, Daniel J.
    Stone, Richard M.
    Sakamaki, Hisashi
    Appelbaum, Frederick R.
    Doehner, Hartmut
    Antin, Joseph H.
    Soiffer, Robert J.
    Cutler, Corey
    [J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2009, 301 (22): : 2349 - 2361
  • [7] Treatment of relapsed/refractory acute myeloid leukaemia in adults
    Rashidi, Armin
    Weisdorf, Daniel J.
    Bejanyan, Nelli
    [J]. BRITISH JOURNAL OF HAEMATOLOGY, 2018, 181 (01) : 27 - 37
  • [8] Maintenance therapy in acute myeloid leukemia: an evidence-based review of randomized trials
    Rashidi, Armin
    Walter, Roland B.
    Tallman, Martin S.
    Appelbaum, Frederick R.
    DiPersio, John F.
    [J]. BLOOD, 2016, 128 (06) : 763 - 773
  • [9] Ten-year outcome of patients with acute myeloid leukemia not treated with allogeneic transplantation in first complete remission
    Vasu, Sumithira
    Kohlschmidt, Jessica
    Mrozek, Krzysztof
    Eisfeld, Ann-Kathrin
    Nicolet, Deedra
    Sterling, Lisa J.
    Becker, Heiko
    Metzeler, Klaus H.
    Papaioannou, Dimitrios
    Powell, Bayard L.
    Kolitz, Jonathan E.
    Moore, Joseph O.
    Baer, Maria R.
    Roboz, Gail J.
    Stone, Richard M.
    Byrd, John C.
    Carroll, Andrew J.
    Bloomfield, Clara D.
    [J]. BLOOD ADVANCES, 2018, 2 (13) : 1645 - 1650
  • [10] Oral Azacitidine Maintenance Therapy for Acute Myeloid Leukemia in First Remission
    Wei, A. H.
    Dohner, H.
    Pocock, C.
    Montesinos, P.
    Afanasyev, B.
    Dombret, H.
    Ravandi, F.
    Sayar, H.
    Jang, J. -H.
    Porkka, K.
    Selleslag, D.
    Sandhu, I.
    Turgut, M.
    Giai, V.
    Ofran, Y.
    Cakar, M. Kizil
    de Sousa, A. Botelho
    Rybka, J.
    Frairia, C.
    Borin, L.
    Beltrami, G.
    Cermak, J.
    Ossenkoppele, G. J.
    La Torre, I.
    Skikne, B.
    Kumar, K.
    Dong, Q.
    Beach, C. L.
    Roboz, G. J.
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2020, 383 (26) : 2526 - 2537
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