Palladacycle-Phosphine Catalyzed Methylation of Amines and Ketones Using Methanol

被引：57
作者：
Marnidala, Ramesh [1 ]
Biswal, Priyabrata [1 ]
Subramani, M. Siva [1 ]
Samser, Shaikh [1 ]
Venkatasubbaiah, Krishnan [1 ]
机构：
[1] HBNI, Natl Inst Sci Educ & Res, Sch Chem Sci, Bhubaneswar 752050, Odisha, India
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2019年 / 84卷 / 16期
关键词：
N-ALKYLATION; TRANSFER HYDROGENATION; REDUCTIVE AMINATION; ALPHA-METHYLATION; COMPLEX BEARING; ALCOHOLS; DEHYDROGENATION; OXIDATION; ALDEHYDES;
D O I：
10.1021/acs.joc.9b00983
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Methylation of amines and ketones with palladacycle precatalyst has been performed using methanol as an environmentally benign reagent. Various ketones and amines undergo methylation reaction to yield monomethylated amines or ketones in moderate to good isolated yields. Moreover, this protocol was tested for the chemoselective methylation of 4-aminobenzenesulfonamide. The scope of the reaction was further extended to the deuteromethylation of ketones.
引用
收藏
页码：10472 / 10480
页数：9
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