Inhaled prostacyclin for term infants with persistent pulmonary hypertension refractory to inhaled nitric oxide

被引：110

作者：

Kelly, LK

Porta, NFM

Goodman, DM

Carroll, CL

Steinhorn, RH

机构：

[1] Childrens Mem Hosp, Dept Pediat, Chicago, IL 60614 USA

[2] Northwestern Univ, Sch Med, Chicago, IL 60614 USA

来源：

JOURNAL OF PEDIATRICS | 2002年 / 141卷 / 06期

关键词：

D O I：

10.1067/mpd.2002.129849

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

We report the use of inhaled prostacyclin (PGI(2)) in 4 neonates with persistent pulmonary hypertension and hypoxemia refractory to inhaled nitric oxide. Oxygenation rapidly improved after inhalation of PGI(2) in all infants. The condition of one infant subsequently deteriorated, and alveolar capillary dysplasia was found at autopsy. The surviving infants were discharged with normal oxygen saturations in room air.

引用

页码：830 / 832

页数：3

共 8 条

[1] AEROSOLIZED PROSTACYCLIN FOR PULMONARY-HYPERTENSION IN NEONATES
BINDL, L
FAHNENSTICH, H
PEUKERT, U
[J]. ARCHIVES OF DISEASE IN CHILDHOOD-FETAL AND NEONATAL EDITION, 1994, 71 (03): : F214 - F216
[2] Low-dose nitric oxide therapy for persistent pulmonary hypertension of the newborn.
Clark, RH
Kueser, TJ
Walker, MW
Southgate, WM
Huckaby, JL
Perez, JA
Roy, BJ
Keszler, M
Kinsella, JP
[J]. NEW ENGLAND JOURNAL OF MEDICINE, 2000, 342 (07) : 469 - 474
[3] Combined inhaled nitric oxide and inhaled prostacyclin during experimental chronic pulmonary hypertension
Hill, LL
Pearl, RG
[J]. JOURNAL OF APPLIED PHYSIOLOGY, 1999, 86 (04) : 1160 - 1164
[4] KAAPA P, 1985, J PEDIATR-US, V107, P951
[5] Mikhail G, 1997, EUR HEART J, V18, P1499
[6] Improvement of oxygenation induced by aerosolized prostacyclin in a preterm infant with persistent pulmonary hypertension of the newborn
Soditt, V
Aring, C
Groneck, P
[J]. INTENSIVE CARE MEDICINE, 1997, 23 (12) : 1275 - 1278
[7] Stork E, 1997, NEW ENGL J MED, V336, P597
[8] INHALED NITRIC-OXIDE VERSUS INHALED PROSTACYCLIN AND INTRAVENOUS VERSUS INHALED PROSTACYLIN IN ACUTE RESPIRATORY-FAILURE WITH PULMONARY-HYPERTENSION IN PIGLETS
ZOBEL, G
DACAR, D
RODL, S
FRIEHS, I
[J]. PEDIATRIC RESEARCH, 1995, 38 (02) : 198 - 204

← 1 →