Possible involvement of Syndecan-1 in the state of COVID-19 related to endothelial injury

被引：27

作者：

Suzuki, Keiko ^{[1
]}

Okada, Hideshi ^{[2
]}

Tomita, Hiroyuki ^{[3
]}

Sumi, Kazuyuki ^{[1
]}

Kakino, Yoshinori ^{[2
]}

Yasuda, Ryu ^{[2
]}

Kitagawa, Yuichiro ^{[2
]}

Fukuta, Tetsuya ^{[2
]}

Miyake, Takahito ^{[2
]}

Yoshida, Shozo ^{[2
]}

Suzuki, Akio ^{[1
]}

Ogura, Shinji ^{[2
]}

机构：

[1] Gifu Univ Hosp, Dept Pharm, Gifu, Japan

[2] Gifu Univ, Grad Sch Med, Dept Emergency & Disaster Med, 1-1 Yanagido, Gifu 5011194, Japan

[3] Gifu Univ, Grad Sch Med, Dept Tumor Pathol, Gifu, Japan

来源：

THROMBOSIS JOURNAL | 2021年 / 19卷 / 01期

关键词：

COVID-19; Syndecan-1; Endothelial glycocalyx; D-dimer;

D O I：

10.1186/s12959-021-00258-x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background The coronavirus infection 2019 (COVID-19) is associated with microvascular endothelial injury. Here, we report that syndecan-1, a component of endothelial glycocalyx, may reflect the disease state of COVID-19 related to endothelial injury. Case presentation A patient with COVID-19 was transferred to the intensive care unit of our hospital. Computed tomography of the chest showed bilateral ground glass opacities, which was diagnosed as acute respiratory syndrome. The PaO2/FIO2 ratio gradually increased from 158 on hospitalization to 300 on Day 11, on which day the ventilator was withdrawn. However, serum syndecan-1 (SDC-1) level gradually decreased from 400.5 ng/ml at hospitalization to 165.1 ng/ml on Day 5. On Day 6, serum SDC-1 level increased to 612.9 ng/ml owing to a systemic thrombosis with an increase in D-dimer. Serum SDC-1 level then decreased until 206.0 ng/ml on Day 11 after a decrease in D-dimer. The patient was transferred to another hospital on Day 21 after hospitalization. Conclusions In this case report, changes in serum SDC-1 level closely reflected the change in disease condition in a patient with COVID-19. Serum SDC-1 may be a useful biomarker for monitoring the disease state of critically ill patients with COVID-19.

引用

页数：5

共 19 条

[1] Endothelial glycocalyx layer shedding following lung resection [J].