MicroRNA expression patterns in oral squamous cell carcinoma: hsa-mir-99b-3p and hsa-mir-100-5p as novel prognostic markers for oral cancer

被引：52

作者：

Jakob, Mark ^{[1
]}

Mattes, Lena M. ^{[2
]}

Kueffer, Stefan ^{[3
]}

Unger, Kristian ^{[4
,5
]}

Hess, Julia ^{[4
,5
]}

Bertlich, Mattis ^{[1
]}

Haubner, Frank ^{[1
]}

Ihler, Friedrich ^{[1
,6
]}

Canis, Martin ^{[1
]}

Weiss, Bernhard G. ^{[1
]}

Kitz, Julia ^{[3
]}

机构：

[1] Ludwig Maximilians Univ Munchen, Klinikum Univ Munchen, Dept Otorhinolaryngol, Marchioninistr 15, D-81377 Munich, Germany

[2] Georg August Univ Gottingen, Univ Med Gottingen, Dept Otorhinolaryngol, Gottingen, Germany

[3] Georg August Univ Gottingen, Univ Med Gottingen, Inst Pathol, Gottingen, Germany

[4] Helmholtz Zentrum Munchen, Res Ctr Environm Hlth GmbH, Clin Cooperat Grp Personalized Radiotherapy Head, Munich, Germany

[5] Helmholtz Zentrum Munchen, Res Ctr Environm Hlth GmbH, Res Unit Radiat Cytogenet, Munich, Germany

[6] Ludwig Maximilians Univ Munchen, Klinikum Univ Munchen, German Ctr Vertigo & Balance Disorders DSGZ, Munich, Germany

来源：

HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK | 2019年 / 41卷 / 10期

关键词：

biomarker; hsa-mir-100-5p; hsa-mir-99b-3p; microRNA; oral squamous cell carcinoma; prognosis; DOWN-REGULATION; HEPATOCELLULAR-CARCINOMA; TUMOR-SUPPRESSOR; HEAD; PROLIFERATION; BIOMARKERS; INVASION; MIR-21; MIR-155; PROMOTES;

D O I：

10.1002/hed.25866

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

Background MicroRNAs (miRNA) recently evolved as potential cancer biomarkers. Therefore, the aim of the present study was to evaluate the prognostic impact of eight miRNAs connected to oral squamous cell carcinoma (OSCC). Method Expression levels of hsa-mir-21-5p, hsa-mir-29b-3p, hsa-mir-31-5p, hsa-mir-99a-5p, hsa-mir-99b-3p, hsa-mir-100-5p, hsa-mir-143-3p and hsa-mir-155-5p were analyzed in tumor tissue (n = 36) and healthy oral mucosal tissue (n = 17) and correlated with clinical variables. Results of the study cohort were validated in an OSCC cohort of The Cancer Genome Atlas. Results Increased hsa-mir-99b-3p expression level showed a tendency toward advanced tumor stages, and high levels of hsa-mir-100-5p expression were associated with extracapsular extension. While a high expression level of hsa-mir-99b-3p was associated with better survival, a high expression level of hsa-mir-100-5p was correlated with a poorer survival in the study cohort. Conclusion Our results indicate that hsa-mir-99b-3p and hsa-mir-100-5p may serve as novel prognostic biomarkers in OSCC.

引用

页码：3499 / 3515

页数：17

共 86 条

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