Cyclic Anhydrides as Powerful Tools for Bioconjugation and Smart Delivery

被引：22

作者：

Spanedda, Maria Vittoria ^{[1
]}

Bourel-Bonnet, Line ^{[1
]}

机构：

[1] Univ Strasbourg, Fac Pharm, Lab Concept & Applicat Mol Bioact, 3Bio Team,ITI InnoVec,UMR 7199,CNRS, F-67401 Illkirch Graffenstaden, France

来源：

BIOCONJUGATE CHEMISTRY | 2021年 / 32卷 / 03期

关键词：

Molecular biology - Targeted drug delivery;

D O I：

10.1021/acs.bioconjchem.1c00023

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Cyclic anhydrides are potent tools for bioconjugation; therefore, they are broadly used in the functionalization of biomolecules and carriers. The pH-dependent stability and reactivity, as well as the physical properties, can be tuned by the structure of the cyclic anhydride used; thus, their application in smart delivery systems has become very important. This review intends to cover the last updates in the use of cyclic anhydrides as pH-sensitive linkers, their differences in reactivity, and the latest applications found in bioconjugation chemistry or chemical biology, and when possible, in drug delivery.

引用

页码：482 / 496

页数：15

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