Cyclic Anhydrides as Powerful Tools for Bioconjugation and Smart Delivery

被引:26
作者
Spanedda, Maria Vittoria [1 ]
Bourel-Bonnet, Line [1 ]
机构
[1] Univ Strasbourg, Fac Pharm, Lab Concept & Applicat Mol Bioact, 3Bio Team,ITI InnoVec,UMR 7199,CNRS, F-67401 Illkirch Graffenstaden, France
关键词
Molecular biology - Targeted drug delivery;
D O I
10.1021/acs.bioconjchem.1c00023
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
Cyclic anhydrides are potent tools for bioconjugation; therefore, they are broadly used in the functionalization of biomolecules and carriers. The pH-dependent stability and reactivity, as well as the physical properties, can be tuned by the structure of the cyclic anhydride used; thus, their application in smart delivery systems has become very important. This review intends to cover the last updates in the use of cyclic anhydrides as pH-sensitive linkers, their differences in reactivity, and the latest applications found in bioconjugation chemistry or chemical biology, and when possible, in drug delivery.
引用
收藏
页码:482 / 496
页数:15
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