Chemical kindling induced by pentylenetetrazol changes cholecystokinin mRNA and peptide levels in rat frontal cortex

被引：5
作者：
Takeda, K
Nakata, K
Chikuma, T
Ito, T
Kato, T
机构：
[1] YOKOHAMA CITY UNIV,GRAD SCH INTEGRATED SCI,LAB MOL RECOGNIT,KANAZAWA KU,YOKOHAMA,KANAGAWA 236,JAPAN
[2] DAINABOT CO LTD,DEPT RES & DEV,CHIBA 271,JAPAN
[3] SHOWA COLL PHARMACEUT SCI,DEPT PHARMACEUT ANALYT CHEM,TOKYO 194,JAPAN
[4] DAINIPPON PHARMACEUT CO LTD,DEV RES LAB,DEPT PHARMACOL & TOXICOL,OSAKA 564,JAPAN
来源：
NEUROSCIENCE LETTERS | 1997年 / 234卷 / 2-3期
关键词：
cholecystokinin mRNA; cholecystokinin-immunoreactivity; chronic; frontal cortex; hippocampus; kindling; pentylenetetrazol;
D O I：
10.1016/S0304-3940(97)00677-0
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Kindling model is useful to study the mechanism of learning and memory. Cholecystokinin (CCK) mRNA and CCK-like immunoreactivity (CCK-LI) levels in the hippocampus and frontal cortex of chemically kindled rats were determined at different time points. In the frontal cortex, chronic treatment with pentylenetetrazol (PTZ) (40 mg/kg per day for 8 days) increased CCK mRNA level at 7 days, and decreased CCK-LI level at 2 and 7 days after the last injection. However, neither CCK mRNA nor CCK-LI levels in the hippocampus changed. These results suggest that PTZ-induced kindling increases CCK mRNA expression and CCK-LI release in the frontal cortex, (C) 1997 Elsevier Science Ireland Ltd.
引用
收藏
页码：115 / 118
页数：4
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