Dermatologic Changes Induced by Repeated Ixodes scapularis Bites and Implications for Prevention of Tick-Borne Infection

被引：41

作者：

Krause, Peter J. ^{[1
,2
]}

Grant-Kels, Jane M. ^{[1
]}

Tahan, Steven R. ^{[3
]}

Dardick, Kenneth R. ^{[1
]}

Alarcon-Chaidez, Francisco ^{[1
]}

Bouchard, Keith ^{[1
]}

Visini, Christine ^{[1
]}

Deriso, Cindy ^{[1
]}

Foppa, Ivo M. ^{[4
]}

Wikel, Stephen ^{[1
]}

机构：

[1] Univ Connecticut, Sch Med, Farmington, CT USA

[2] Connecticut Childrens Med Ctr, Hartford, CT USA

[3] Harvard Univ, Sch Med, Boston, MA 02115 USA

[4] Tulane Sch Publ Hlth & Trop Med, New Orleans, LA USA

来源：

VECTOR-BORNE AND ZOONOTIC DISEASES | 2009年 / 9卷 / 06期

基金：

美国国家卫生研究院;

关键词：

Ixodes; Tick(s); Immunology; Lyme disease; BORRELIA-BURGDORFERI TRANSMISSION; PATHOGEN-FREE NYMPHS; LYME-DISEASE VECTOR; CYTOKINE RESPONSES; SALIVA; PROTEIN; HYPERSENSITIVITY; VASCULOPATHY; MODULATION; EXPRESSION;

D O I：

10.1089/vbz.2008.0091

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Previous studies in rodents and people have demonstrated that repeated tick exposure is associated with reduced Borrelia burgdorferi transmission but the mechanism of prevention remains unclear. We examined the acute histopathologic reactions to initial and repeated Ixodes scapularis bites in BALB/c mice and in people. Skin biopsies of BALB/c mice infested for the first time by I. scapularis nymphs revealed vascular dilatation and an accumulation of inflammatory cells adjacent to the bite site but absent at the site of tick attachment. Such changes would enhance tick-borne pathogen transmission. Mice reexposed to I. scapularis nymphs experienced a decrease in vascular dilatation and a marked increase in inflammatory cells at the site of tick attachment. Skin biopsies of people with attached I. scapularis nymphs revealed similar histologic patterns. These results indicate that cellular changes at the tick-dermal interface following I. scapularis attachment are likely to allow for successful transmission of tick-borne pathogens in non-tick-immune hosts and to inhibit tick-borne pathogen transmission in hosts that have developed tick immunity.

引用

页码：603 / 610

页数：8

共 60 条

[11] Effect of tick removal on transmission of Borrelia burgdorferi and Ehrlichia phagocytophila by Ixodes scapularis nymphs [J].

des Vignes, F ;

Piesman, J ;

Heffernan, R ;

Schulze, TL ;

Stafford, KC ;

Fish, D .

JOURNAL OF INFECTIOUS DISEASES, 2001, 183 (05) :773-778

[12] Uninfected mosquito bites confer protection against infection with malaria parasites [J].

Donovan, Michael J. ;

Messmore, Andrew S. ;

Scrafford, Deborah A. ;

Sacks, David L. ;

Kamhawi, Shaden ;

McDowell, Mary Ann .

INFECTION AND IMMUNITY, 2007, 75 (05) :2523-2530

[13] Ehrlichioses in humans: Epidemiology, clinical presentation, diagnosis, and treatment [J].

Dumler, J. Stephen ;

Madigan, John E. ;

Pusterla, Nicola ;

Bakken, Johan S. .

CLINICAL INFECTIOUS DISEASES, 2007, 45 :S45-S51

[14] Multiple pruritic papules from lone star tick larvae bites [J].

Fisher, EJ ;

Mo, J ;

Lucky, AW .

ARCHIVES OF DERMATOLOGY, 2006, 142 (04) :491-494

[15] Tick mouth parts occlusive vasculopathy: a localized cryoglobulinemic vasculitic response [J].

Galaria, NA ;

Chaudhary, O ;

Magro, CM .

JOURNAL OF CUTANEOUS PATHOLOGY, 2003, 30 (05) :303-306

[16] Cutting edge: CD4 is the receptor for the tick saliva immunosuppressor, Salp15 [J].

Garg, Renu ;

Juncadella, Ignacio J. ;

Ramamoorthi, Nandhini ;

Ashish ;

Ananthanarayanan, Shobana K. ;

Thomas, Venetta ;

Rincon, Mercedes ;

Krueger, Joanna K. ;

Fikrig, Erol ;

Yengo, Christopher M. ;

Anguita, Juan .

JOURNAL OF IMMUNOLOGY, 2006, 177 (10) :6579-6583

[17] DIFFERENTIAL CELLULAR-RESPONSES AT HYALOMMA-ANATOLICUM-ANATOLICUM FEEDING SITES ON SUSCEPTIBLE AND TICK-RESISTANT RABBITS [J].

GILL, HS ;

WALKER, AR .

PARASITOLOGY, 1985, 91 (DEC) :591-607

[18] Identification of an IL-2 binding protein in the saliva of the lyme disease vector tick, Ixodes scapularis [J].

Gillespie, RD ;

Dolan, MC ;

Piesman, J ;

Titus, RG .

JOURNAL OF IMMUNOLOGY, 2001, 166 (07) :4319-4326

[19]

Ginsberg HS, 2005, TICK-BORNE DISEASES OF HUMANS, P65

[20]

Hanincová K, 2006, EMERG INFECT DIS, V12, P604

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