Catalytic conjugate addition of allyl groups to styryl-activated enones

被引：89

作者：

Sieber, Joshua D.

Liu, Shubin

Morken, James P. ^{[1
]}

机构：

[1] Boston Coll, Dept Chem, Merkert Chem Ctr, Chestnut Hill, MA 02467 USA

[2] Univ N Carolina, Informat Technol Serv, Div Res Comp, Chapel Hill, NC 27599 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2007年 / 129卷 / 08期

关键词：

D O I：

10.1021/ja067878w

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Conjugate addition of pinacolato(allyl)boron to benzylidenealkylidene ketones is remarkably facile when catalyzed by Ni(0) and Pd(0) complexes. Simple enones are inert to the reaction conditions, suggesting a significant activating effect by the auxiliary benzylidene unit. A comparison of different catalysts and substrates is provided, as is a mechanistic rationale, and an example of asymmetric catalysis.

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页码：2214 / +

页数：3

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