Can We Prevent Obesity-Related Metabolic Diseases by Dietary Modulation of the Gut Microbiota?

被引：97

作者：

Brahe, Lena K. ^{[1
]}

Astrup, Arne ^{[1
]}

Larsen, Lesli H. ^{[1
]}

机构：

[1] Univ Copenhagen, Fac Sci, Dept Nutr Exercise & Sports, Copenhagen, Denmark

来源：

ADVANCES IN NUTRITION | 2016年 / 7卷 / 01期

关键词：

gut microbiota; diet; prebiotics; probiotics; obesity-related diseases; HIGH-FAT-DIET; LIPOPOLYSACCHARIDE-BINDING PROTEIN; BODY-MASS INDEX; INTESTINAL PERMEABILITY; CARDIOVASCULAR-DISEASE; LACTOBACILLUS-REUTERI; FECAL MICROBIOTA; GLYCEMIC INDEX; WEIGHT-LOSS; ENDOTOXEMIA;

D O I：

10.3945/an.115.010587

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Obesity increases the risk of type 2 diabetes, cardiovascular diseases, and certain cancers, which are among the leading causes of death worldwide. Obesity and obesity-related metabolic diseases are characterized by specific alterations in the human gut microbiota. Experimental studies with gut microbiota transplantations in mice and in humans indicate that a specific gut microbiota composition can be the cause and not just the consequence of the obese state and metabolic disease, which suggests a potential for gut microbiota modulation in prevention and treatment of obesity-related metabolic diseases. In addition, dietary intervention studies have suggested that modulation of the gut microbiota can improve metabolic risk markers in humans, but a causal role of the gut microbiota in such studies has not yet been established. Here, we review and discuss the role of the gut microbiota in obesity-related metabolic diseases and the potential of dietary modulation of the gut microbiota in metabolic disease prevention and treatment.

引用

页码：90 / 101

页数：12

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