Emerging concepts in liquid biopsies

被引：209

作者：

Perakis, Samantha ^{[1
]}

Speicher, Michael R. ^{[1
,2
]}

机构：

[1] Med Univ Graz, Inst Human Genet, Harrachgasse 21-8, A-8010 Graz, Austria

[2] BioTechMed, Graz, Austria

来源：

BMC MEDICINE | 2017年 / 15卷

关键词：

Cell-free DNA; Circulating tumor DNA; Circulating tumor cells; Liquid biopsy; Disease monitoring; Precision medicine; CIRCULATING TUMOR-CELLS; PLASMA DNA; INTRATUMOR HETEROGENEITY; ACQUIRED-RESISTANCE; SOMATIC MUTATIONS; SINGLE-NUCLEOTIDE; CLONAL EVOLUTION; CANCER EXOSOMES; RARE MUTATIONS; NUMBER;

D O I：

10.1186/s12916-017-0840-6

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Characterizing and monitoring tumor genomes with blood samples could achieve significant improvements in precision medicine. As tumors shed parts of themselves into the circulation, analyses of circulating tumor cells, circulating tumor DNA, and tumor-derived exosomes, often referred to as "liquid biopsies", may enable tumor genome characterization by minimally invasive means. Indeed, multiple studies have described how molecular information about parent tumors can be extracted from these components. Here, we briefly summarize current technologies and then elaborate on emerging novel concepts that may further propel the field. We address normal and detectable mutation levels in the context of our current knowledge regarding the gradual accumulation of mutations during aging and in light of technological limitations. Finally, we discuss whether liquid biopsies are ready to be used in routine clinical practice.

引用

页数：12

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