Myosin heavy chain isoforms in smooth muscle

被引：16

作者：

Loukianov, E

Loukianova, T

Periasamy, M

机构：

[1] UNIV CINCINNATI,COLL MED,DIV CARDIOL,SECT MOL CARDIOL,CINCINNATI,OH 45267

[2] UNIV CINCINNATI,COLL MED,CARDIOVASC RES CTR,CINCINNATI,OH 45267

来源：

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY | 1997年 / 117卷 / 01期

关键词：

smooth muscle cells; myosin heavy chain; isoform; expression; differentiation; development; exon; tissue-specific;

D O I：

10.1016/S0305-0491(96)00309-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In recent years, significant progress has been made toward understanding smooth muscle myosin heavy chain (SMHC) structure. Molecular cloning analysis has identified four different MHC isoforms. They are products of a single gene and result from alternative mRNA splicing. In addition, two non-muscle MHC isoforms are also expressed in smooth muscle cells. Studies show that SMHC expression is highly tissue specific and does not appear in cardiac or skeletal muscle cells. Each smooth muscle tissue is characterized by a specific pattern of MHC isoform expression that changes during development and disease. This review essentially focuses on SMHC isoforms and their expression in mammals. (C) 1997 Elsevier Science Inc.

引用

页码：13 / 18

页数：6

共 51 条

[1] HUMAN SMOOTH-MUSCLE MYOSIN HEAVY-CHAIN ISOFORMS AS MOLECULAR MARKERS FOR VASCULAR DEVELOPMENT AND ATHEROSCLEROSIS [J].