Adsorption of the cis-[Pt(NH3)2(P2O7)]2- (phosphaplatin) on hydroxyapatite nanocrystals as a smart way to selectively release activated cis-[Pt(NH3)2Cl2] (cisplatin) in tumor tissues

被引：22
|
作者：
Benedetti, Michele [1 ]
De Castro, Federica [1 ]
Romano, Alessandro [2 ]
Migoni, Danilo [1 ]
Piccinni, Barbara [1 ]
Verri, Tiziano [1 ]
Lelli, Marco [3 ]
Roveri, Norberto [3 ]
Fanizzi, Francesco P. [1 ]
机构：
[1] Univ Salento, Dept Biol & Environm Sci & Technol, Via Monteroni, I-73100 Lecce, Italy
[2] Ist Sci San Raffaele, IRCCS, Div Neurosci, Neuropathol Unit,Inst Expt Neurol, Via Olgettina 60, I-20132 Milan, Italy
[3] Bioecoactive Srl, Via San Donato 5, I-40057 Bologna, Italy
来源：
JOURNAL OF INORGANIC BIOCHEMISTRY | 2016年 / 157卷
关键词：
cisplatin; phosphaplatin; Platinum drug; Antitumor drug; Hydroxyapatite; Nanoparticles; CALCIUM-PHOSPHATE NANOPARTICLES; PLATINUM ANTITUMOR COMPOUNDS; N7-PLATINATED GUANINES; CHIRAL DISCRIMINATION; CIRCULAR-DICHROISM; ANTICANCER DRUGS; COMPLEXES; DNA; DELIVERY; NMR;
D O I：
10.1016/j.jinorgbio.2016.01.019
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The relevant adsorption of cis-[Pt(NH3)(2)(P2O7)](2-) (phosphaplatin) on hydroxyapatite nanocrystals (nHAP) was observed and studied in water suspension. Phosphaplatin cytotoxicity, which is very low for HeLa, MCF-7 and HS-5 cell lines could be enhanced, reaching that of cisplatin, by interaction with solid nHAP. This effect stems from nHAP ability to catalyze the phosphaplatin hydrolysis, producing the same hydrolytic species responsible for cisplatin antitumor activity. (C) 2016 Elsevier Inc. All rights reserved.
引用
收藏
页码：73 / 79
页数：7
相关论文
共 50 条
  • [41] Synthesis and Antitumour Activity of a New Trinuclear Platinum Compound [{cis-PtCl(NH3)2μ {trans-Pt(3-hydroxypyridine)2H2N(CH2)5NH2)2}] Cl4 in Human Ovarian Cancer Cells
    Hamad, Shahnaz A.
    Beale, Philip
    Yu, Jun Qing
    Huq, Fazlul
    ANTICANCER RESEARCH, 2014, 34 (04) : 1923 - 1929
  • [42] Influence mechanism of Pd, Pt, Rh/γ-Al2O3 on NH3 formation for NO reduction by CO
    Wang, Houlin
    Peng, Yue
    Si, Wenzhe
    Gao, Chuan
    Wang, Yunlong
    Wang, Rong
    Yuan, Jin
    Zhou, Bin
    Li, Junhua
    APPLIED CATALYSIS B-ENVIRONMENT AND ENERGY, 2024, 352
  • [43] Di- and trinuclear phosphido-bridged platinum complexes. Crystal structures of [Pt{CH2=CHC(O)OMe}(PPh3)2], trans-[Pt2(μ-PPh2)2I2(PPh3)2] and cis,cis,cis-[Pt3(μ-I)2(μ-PPh2)2Cl0.5I1.5(PPh3)2]
    Bender, Robert
    Okio, Coco
    Welter, Richard
    Braunstein, Pierre
    DALTON TRANSACTIONS, 2009, (25) : 4901 - 4907
  • [44] The State of Platinum and Structural Features of Pt/Al2O3 Catalysts in the Reaction of NH3 Oxidation
    Svintsitskiy, D. A.
    Slavinskaya, E. M.
    Stonkus, O. A.
    Romanenko, A. V.
    Stadnichenko, A. I.
    Kibis, L. S.
    Derevyannikova, E. A.
    Evtushkova, A. A.
    Boronin, A. I.
    JOURNAL OF STRUCTURAL CHEMISTRY, 2019, 60 (06) : 919 - 931
  • [45] The effect of cis-diamminedichloroplatinum, selenite and a conjugate of cisplatin with selenite [(NH3)2Pt(SeO3)] on oxidative stress in blood platelets measured by chemiluminescence method
    Olas, B
    Zbikowska, HM
    Wachowicz, B
    Buczynski, A
    Krajewski, T
    JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, 1999, 50 (02): : 299 - 308
  • [46] Synthesis and X-ray crystal structure analysis of 1: 1 and 1:2 complexes of cisplatin with the model nucleobase 9-methyladenine in its protonated form and a unique HNO3 adduct of cis-[(NH3)2Pt(9-MeAH-N7)2]4+
    Bivián-Castro, EY
    Roitzsch, M
    Gupta, D
    Lippert, B
    INORGANICA CHIMICA ACTA, 2005, 358 (07) : 2395 - 2402
  • [47] The effect of geometric isomerism on the anticancer activity of the monofunctional platinum complex trans-[Pt(NH3)2(phenanthridine)Cl]NO3
    Zhou, Wen
    Almeqdadi, Mohammad
    Xifaras, Michael E.
    Riddell, Imogen A.
    Yilmaz, Omer H.
    Lippard, Stephen J.
    CHEMICAL COMMUNICATIONS, 2018, 54 (22) : 2788 - 2791
  • [48] Synthesis and characterization of the novel Pt(II) complexes of the types cis- and trans-Pt(Ypy)(pyrazine)Cl2, K2[Cl3Pt(μ-pyrazine)PtCl3] and trans,trans-(Ypy)Cl2Pt(μ-pyrazine)Pt(Ypy)Cl2 (Ypy = pyridine derivative)
    Rochon, Fernande D.
    Fakhfakh, Majd
    INORGANICA CHIMICA ACTA, 2009, 362 (02) : 458 - 470
  • [49] Synthesis, crystal structure and antimicrobial studies of a thione derivative of transplatin, trans-[Pt(NH3)2(Diaz)2]Cl2•2H2O (Diaz=1,3-diazinane-2-thione)
    Seerat-ur-Rehman
    Isab, Anvarhusein A.
    Tahir, Muhammad Nawaz
    Khalid, Tanzeel
    Saleem, Muhammad
    Sadaf, Haseeba
    Ahmad, Saeed
    INORGANIC CHEMISTRY COMMUNICATIONS, 2013, 36 : 68 - 71
  • [50] Trifluoroacetylacetonate rhodium(III) methyl complexes, cis-[Rh(TFA)(PPh3)2(CH3)(L)][BPh4] and cis-[Rh(TFA)(PPh3)2(CH3)(I)] (L = CH3CN, NH3, pyridine), in comparison with their acetylacetonate analogs
    Shestakova, Elizaveta P.
    Varshavsky, Yuri S.
    Khrustalev, Viktor N.
    Smirnov, Sergei N.
    Podkorytov, Ivan S.
    Borisova, Marina V.
    Nikolskii, Aleksei B.
    JOURNAL OF ORGANOMETALLIC CHEMISTRY, 2011, 696 (20) : 3214 - 3222
12345