Adsorption of the cis-[Pt(NH3)2(P2O7)]2- (phosphaplatin) on hydroxyapatite nanocrystals as a smart way to selectively release activated cis-[Pt(NH3)2Cl2] (cisplatin) in tumor tissues

被引：22
|
作者：
Benedetti, Michele [1 ]
De Castro, Federica [1 ]
Romano, Alessandro [2 ]
Migoni, Danilo [1 ]
Piccinni, Barbara [1 ]
Verri, Tiziano [1 ]
Lelli, Marco [3 ]
Roveri, Norberto [3 ]
Fanizzi, Francesco P. [1 ]
机构：
[1] Univ Salento, Dept Biol & Environm Sci & Technol, Via Monteroni, I-73100 Lecce, Italy
[2] Ist Sci San Raffaele, IRCCS, Div Neurosci, Neuropathol Unit,Inst Expt Neurol, Via Olgettina 60, I-20132 Milan, Italy
[3] Bioecoactive Srl, Via San Donato 5, I-40057 Bologna, Italy
来源：
JOURNAL OF INORGANIC BIOCHEMISTRY | 2016年 / 157卷
关键词：
cisplatin; phosphaplatin; Platinum drug; Antitumor drug; Hydroxyapatite; Nanoparticles; CALCIUM-PHOSPHATE NANOPARTICLES; PLATINUM ANTITUMOR COMPOUNDS; N7-PLATINATED GUANINES; CHIRAL DISCRIMINATION; CIRCULAR-DICHROISM; ANTICANCER DRUGS; COMPLEXES; DNA; DELIVERY; NMR;
D O I：
10.1016/j.jinorgbio.2016.01.019
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The relevant adsorption of cis-[Pt(NH3)(2)(P2O7)](2-) (phosphaplatin) on hydroxyapatite nanocrystals (nHAP) was observed and studied in water suspension. Phosphaplatin cytotoxicity, which is very low for HeLa, MCF-7 and HS-5 cell lines could be enhanced, reaching that of cisplatin, by interaction with solid nHAP. This effect stems from nHAP ability to catalyze the phosphaplatin hydrolysis, producing the same hydrolytic species responsible for cisplatin antitumor activity. (C) 2016 Elsevier Inc. All rights reserved.
引用
收藏
页码：73 / 79
页数：7
相关论文
共 50 条
  • [31] Synthesis and Activity of [{Cis-PtCl(NH3)2}2μ{Trans-Pt(3-Hydroxypyridine)2(H2N(CH2)6NH2)2}]Cl4 in the Human Ovarian Tumour Models
    Hamad, Shahnaz A. H.
    Beale, Philip
    Yu, Jun Qing
    Fisher, Keith
    Huq, Fazlul
    MEDICINAL CHEMISTRY, 2012, 8 (03) : 384 - 391
  • [32] Potentiation of cytotoxic action of cis-[PtCl2(NH3)(1M7AI)] by UVA irradiation. Mechanistic insights
    Pracharova, Jitka
    Intini, Francesco P.
    Natile, Giovanni
    Kasparkova, Jana
    Brabec, Viktor
    INORGANICA CHIMICA ACTA, 2018, 472 : 199 - 206
  • [33] Cis-diammineplatinum(II) forms a macrochelate with 2′-deoxycytidine 5′-monophosphate (dCMP2-)!: Reactivity and acid-base properties of cis-Pt(NH3)2(dCMP)
    Oswald, G
    Rombeck, I
    Song, B
    Sigel, H
    Lippert, B
    JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY, 1998, 3 (03): : 236 - 245
  • [34] Crystal structure and antimicrobial activity of a transplatin adduct of N,N'-dimethylthiourea, trans-[Pt(NH3)2(dmtu)2]Cl2
    Ahmad, Saeed
    Seerat-ur-Rehman
    Rueffer, Tobias
    Khalid, Tanzeel
    Isab, Anvarhusein A.
    Al-Arfaj, Abdul Rahman
    Saleem, Muhammad
    Ejaz
    Khan, Islam Ullah
    Choudhary, Muhammad Aziz
    MONATSHEFTE FUR CHEMIE, 2017, 148 (04): : 669 - 674
  • [35] Studies on Synthesis, Activity and Binding with DNA of a New Trinuclear Platinum Compound [{trans-PtCl(NH3)2}2{trans-Pt(thiazole)2} {H2N(CH2)6 NH2}2]Cl3(NO3)
    Al-Shuneigat, Jehad
    Qing, Yu
    Beale, Philip
    Fisher, Keith
    Huq, Fazlul
    MEDICINAL CHEMISTRY, 2011, 7 (01) : 1 - 8
  • [36] Multinuclear magnetic resonance studies of the reactions of the antitumor complexes cis-Pt(L)2X2 and cis-Pt(NH3)(L)X2 (L = cyclobutylamine and cyclopentylamine) with guanosine and other bases and crystal structures of Pt(cyclopentylamine)2I2
    Rochon, Fernande D.
    Beauchamp, Andre L.
    Dion, Chantal
    INORGANICA CHIMICA ACTA, 2009, 362 (11) : 3885 - 3895
  • [37] Synthesis, characterization and catalytic activity in the carbonylation of ethene of cis-[Pd(H2O)2(PPh3)2]X2•nH2O (X = p-CH3C6H4SO3, n=2;: X = CH3SO3, n=0).: X-ray structure of cis-[Pd(H2O)2(PPh3)2](p-CH3C6H4SO3)2•2H2O and of cis-[Pd(H2O)2(PPh3)2](CH3SO3)2•2CH2Cl2
    Cavinato, G
    Vavasori, A
    Toniolo, L
    Dolmella, A
    INORGANICA CHIMICA ACTA, 2004, 357 (09) : 2737 - 2747
  • [38] Cisplatin and valproate released from the bifunctional [Pt(IV)Cl2(NH3)2(valproato)2] antitumor prodrug or from liposome formulations: who does what?
    Ravera, M.
    Gabano, E.
    Zanellato, I.
    Gallina, A.
    Perin, E.
    Arrais, A.
    Cantamessa, S.
    Osella, D.
    DALTON TRANSACTIONS, 2017, 46 (05) : 1559 - 1566
  • [39] Multinuclear magnetic resonance studies of the hydrolyzed and aquated species of the antitumor complexes cis-Pt(cyclobutylamine)2X2 and cis-Pt(NH3)(cyclobutylamine)X2 and antitumor testing of mixed-amine Pt(II) compounds
    Dion, Chantal
    Beauchamp, Andre L.
    Rochon, Fernande D.
    INORGANICA CHIMICA ACTA, 2009, 362 (06) : 1887 - 1894
  • [40] Structure of duplex DNA containing the cisplatin 1,2-{Pt(NH3)2}2+-d(GpG) cross-link at 1.77 Å resolution
    Todd, Ryan C.
    Lippard, Stephen J.
    JOURNAL OF INORGANIC BIOCHEMISTRY, 2010, 104 (09) : 902 - 908
12345