Adsorption of the cis-[Pt(NH3)2(P2O7)]2- (phosphaplatin) on hydroxyapatite nanocrystals as a smart way to selectively release activated cis-[Pt(NH3)2Cl2] (cisplatin) in tumor tissues

被引：23

作者：

Benedetti, Michele ^{[1
]}

De Castro, Federica ^{[1
]}

Romano, Alessandro ^{[2
]}

Migoni, Danilo ^{[1
]}

Piccinni, Barbara ^{[1
]}

Verri, Tiziano ^{[1
]}

Lelli, Marco ^{[3
]}

Roveri, Norberto ^{[3
]}

Fanizzi, Francesco P. ^{[1
]}

机构：

[1] Univ Salento, Dept Biol & Environm Sci & Technol, Via Monteroni, I-73100 Lecce, Italy

[2] Ist Sci San Raffaele, IRCCS, Div Neurosci, Neuropathol Unit,Inst Expt Neurol, Via Olgettina 60, I-20132 Milan, Italy

[3] Bioecoactive Srl, Via San Donato 5, I-40057 Bologna, Italy

来源：

JOURNAL OF INORGANIC BIOCHEMISTRY | 2016年 / 157卷

关键词：

cisplatin; phosphaplatin; Platinum drug; Antitumor drug; Hydroxyapatite; Nanoparticles; CALCIUM-PHOSPHATE NANOPARTICLES; PLATINUM ANTITUMOR COMPOUNDS; N7-PLATINATED GUANINES; CHIRAL DISCRIMINATION; CIRCULAR-DICHROISM; ANTICANCER DRUGS; COMPLEXES; DNA; DELIVERY; NMR;

D O I：

10.1016/j.jinorgbio.2016.01.019

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The relevant adsorption of cis-[Pt(NH3)(2)(P2O7)](2-) (phosphaplatin) on hydroxyapatite nanocrystals (nHAP) was observed and studied in water suspension. Phosphaplatin cytotoxicity, which is very low for HeLa, MCF-7 and HS-5 cell lines could be enhanced, reaching that of cisplatin, by interaction with solid nHAP. This effect stems from nHAP ability to catalyze the phosphaplatin hydrolysis, producing the same hydrolytic species responsible for cisplatin antitumor activity. (C) 2016 Elsevier Inc. All rights reserved.

引用

页码：73 / 79

页数：7

共 47 条

[11] Water-soluble Organometallic Analogues of Oxaliplatin with Cytotoxic and Anticlonogenic Activity [J].

Benedetti, Michele ;

Antonucci, Daniela ;

Migoni, Danilo ;

Vecchio, Vita M. ;

Ducani, Cosimo ;

Fanizzi, Francesco P. .

CHEMMEDCHEM, 2010, 5 (01) :46-51

[12] Possible Incorporation of Free N7-Platinated Guanines in DNA by DNA Polymerases, Relevance for the Cisplatin Mechanism of Action [J].

Benedetti, Michele ;

Ducani, Cosimo ;

Migoni, Danilo ;

Antonucci, Daniela ;

Vecchio, Vita M. ;

Romano, Alessandro ;

Verri, Tiziano ;

Fanizzi, Francesco P. .

PLATINUM AND OTHER HEAVY METAL COMPOUNDS IN CANCER CHEMOTHERAPY: MOLECULAR MECHANISMS AND CLINICAL APPLICATIONS, 2009, :125-+

[13] Adsorption and release of gemcitabine hydrochloride and oxaliplatin by hydroxyapatite [J].

Betsiou, Maria ;

Bantsis, Georgios ;

Zoi, Ioanna ;

Sikalidis, Constantinos .

CERAMICS INTERNATIONAL, 2012, 38 (04) :2719-2724

[14] pDNA loaded calcium phosphate nanoparticles: highly efficient non-viral vector for gene delivery [J].

Bisht, S ;

Bhakta, G ;

Mitra, S ;

Maitra, A .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2005, 288 (01) :157-168

[15] Absence of Activation of DNA Repair Genes and Excellent Efficacy of Phosphaplatins against Human Ovarian Cancers: Implications To Treat Resistant Cancers [J].

Bose, Rathindra N. ;

Moghaddas, Shadi ;

Belkacemi, Louiza ;

Tripathi, Swarnendu ;

Adams, Nyssa R. ;

Majmudar, Pooja ;

McCall, Kelly ;

Dezvareh, Homa ;

Nislow, Corey .

JOURNAL OF MEDICINAL CHEMISTRY, 2015, 58 (21) :8387-8401

[16] Non-DNA-binding platinum anticancer agents: Cytotoxic activities of platinum-phosphato complexes towards human ovarian cancer cells [J].

Bose, Rathindra N. ;

Maurmann, Leila ;

Mishur, Robert J. ;

Yasui, Linda ;

Gupta, Shefalika ;

Grayburn, W. Scott ;

Hofstetter, Heike ;

Milton, Tara .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (47) :18314-18319

[17] P-31 NMR AND KINETIC-STUDIES OF THE FORMATION OF ORTHOPHOSPHATO, PYROPHOSPHATO, AND TRIPHOSPHATO COMPLEXES OF CIS-DICHLORODIAMMINEPLATINUM(II) [J].

BOSE, RN ;

VIOLA, RE ;

CORNELIUS, RD .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1984, 106 (11) :3336-3343

[18] Transport of platinum bonded nucleotides into proteoliposomes, mediated by Drosophila melanogaster thiamine pyrophosphate carrier protein (DmTpc1) [J].

Carrisi, Chiara ;

Antonucci, Daniela ;

Lunetti, Paola ;

Migoni, Danilo ;

Girelli, Chiara R. ;

Dolce, Vincenza ;

Fanizzi, Francesco P. ;

Benedetti, Michele ;

Capobianco, Loredana .

JOURNAL OF INORGANIC BIOCHEMISTRY, 2014, 130 :28-31

[19]

Cheng XG, 2007, INT J NANOMED, V2, P667

[20]

Chian LS., 2004, BIOMATERIALS, V25, P189

← 1 2 3 4 5 →