Adsorption of the cis-[Pt(NH3)2(P2O7)]2- (phosphaplatin) on hydroxyapatite nanocrystals as a smart way to selectively release activated cis-[Pt(NH3)2Cl2] (cisplatin) in tumor tissues

被引：23
作者：
Benedetti, Michele [1 ]
De Castro, Federica [1 ]
Romano, Alessandro [2 ]
Migoni, Danilo [1 ]
Piccinni, Barbara [1 ]
Verri, Tiziano [1 ]
Lelli, Marco [3 ]
Roveri, Norberto [3 ]
Fanizzi, Francesco P. [1 ]
机构：
[1] Univ Salento, Dept Biol & Environm Sci & Technol, Via Monteroni, I-73100 Lecce, Italy
[2] Ist Sci San Raffaele, IRCCS, Div Neurosci, Neuropathol Unit,Inst Expt Neurol, Via Olgettina 60, I-20132 Milan, Italy
[3] Bioecoactive Srl, Via San Donato 5, I-40057 Bologna, Italy
来源：
JOURNAL OF INORGANIC BIOCHEMISTRY | 2016年 / 157卷
关键词：
cisplatin; phosphaplatin; Platinum drug; Antitumor drug; Hydroxyapatite; Nanoparticles; CALCIUM-PHOSPHATE NANOPARTICLES; PLATINUM ANTITUMOR COMPOUNDS; N7-PLATINATED GUANINES; CHIRAL DISCRIMINATION; CIRCULAR-DICHROISM; ANTICANCER DRUGS; COMPLEXES; DNA; DELIVERY; NMR;
D O I：
10.1016/j.jinorgbio.2016.01.019
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The relevant adsorption of cis-[Pt(NH3)(2)(P2O7)](2-) (phosphaplatin) on hydroxyapatite nanocrystals (nHAP) was observed and studied in water suspension. Phosphaplatin cytotoxicity, which is very low for HeLa, MCF-7 and HS-5 cell lines could be enhanced, reaching that of cisplatin, by interaction with solid nHAP. This effect stems from nHAP ability to catalyze the phosphaplatin hydrolysis, producing the same hydrolytic species responsible for cisplatin antitumor activity. (C) 2016 Elsevier Inc. All rights reserved.
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收藏
页码：73 / 79
页数：7
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